Actively Recruiting
Facilitating Diagnostics and Prognostics of Parkinsonian Syndromes Using Neuroimaging
Led by University of Texas Southwestern Medical Center · Updated on 2026-01-27
90
Participants Needed
1
Research Sites
405 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goals of this study are: 1) to identify biomarkers using neuroimaging that are associated with progression rate using statistical methods, and 2) to identify biomarkers that are associated with the differential diagnosis of Parkinson's disease and atypical parkinsonism.
CONDITIONS
Official Title
Facilitating Diagnostics and Prognostics of Parkinsonian Syndromes Using Neuroimaging
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of Parkinson disease with sufficient clinical data to determine progression rate (fast or slow) and availability of a matched participant in the alternate progression group
- Willingness to participate in required imaging studies and provide written informed consent
- Parkinson disease duration less than 5 years for newly recruited PD subjects
- Multiple system atrophy diagnosis less than 5 years for newly recruited MSA subjects
- Probable progressive supranuclear palsy diagnosis for PSP subjects, willing to participate in imaging and clinical visits
- Control subjects roughly age and sex matched with PD cohort, with no history or signs of neurodegenerative disease and normal gait, balance, and eye movements for age
- Subjects and investigators agree participant is likely able to complete the 2-year study without plans to move
You will not qualify if you...
- Contraindications to multimodal imaging
- Females of child-bearing potential aged 18-55 unless pregnancy test confirms not pregnant prior to scanning
- Non-English speakers
- Right-handed finger amputees or with cast on right hand/fingers at enrollment
- Clinically significant liver, kidney, lung, metabolic, hormone, heart, infectious disease, or medical comorbidity posing safety risk
- History of severe drug allergy or hypersensitivity
- History of drug, alcohol, or substance dependence or abuse within last year or prolonged prior history
- Currently undergoing chemotherapy or radiation for cancer
- Recreational drug use in past six months
- Central nervous system disease or brain injury precluding participation
- Psychiatric or neurological disorder precluding participation
- Inability to keep or maintain research appointments
- Severe disease progression making imaging participation impossible or difficult (Aim 1)
- Absence of suitable matched participant in alternate progression group (Aim 1)
- For PD subjects: presence of cerebellar abnormalities, downward vertical gaze limitation, diagnosis of frontotemporal dementia or primary progressive aphasia, parkinsonian features limited to lower limbs over 3 years, dopamine blocker treatment, no levodopa response, alternative diagnosis more likely, rapid gait impairment progression, no motor symptom progression, early bulbar dysfunction, respiratory dysfunction, severe early autonomic failure, recurrent falls, dystonic contractures, absence of common non-motor PD features, unexplained pyramidal signs, or bilateral symmetric parkinsonism (Aim 2)
- For MSA subjects: significant neuropathy, non-drug-induced hallucinations, onset after age 75, family history of ataxia or parkinsonism, white matter lesions suggesting multiple sclerosis (Aim 2)
- For PSP subjects: unexplained episodic memory impairment, autonomic failure, visual hallucinations, upper and lower motor neuron signs, sudden or rapid symptom progression suggestive of other diseases, history of encephalitis, prominent appendicular ataxia, identifiable cause of postural instability (Aim 2)
- Control subjects deemed unsuitable by investigator (Aim 2)
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
UT Southwestern Medical Center
Dallas, Texas, United States, 75390
Actively Recruiting
Research Team
P
Padraig E O'Suilleabhain, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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