Actively Recruiting
Factors Affecting Post-transplant Cyclophosphamide (PTCy) Efficacy
Led by Wake Forest University Health Sciences · Updated on 2026-01-08
120
Participants Needed
1
Research Sites
889 weeks
Total Duration
On this page
Sponsors
W
Wake Forest University Health Sciences
Lead Sponsor
A
Atrium Health Levine Cancer Institute
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study will examine the influence of donor and recipient pharmacogenetics (PG), drug pharmacokinetics (PK), and T cell phenotypes and how it may permit a tailored dosing strategy to improve the therapeutic index of post-transplant cyclophosphamide (PTCy) and optimize the graft versus tumor effect, while minimizing acute and chronic graft versus host disease (GVHD).
CONDITIONS
Official Title
Factors Affecting Post-transplant Cyclophosphamide (PTCy) Efficacy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed informed consent and HIPAA authorization
- Age 18 years or older at consent
- Scheduled as recipient or donor for haplo-identical, matched related, or matched unrelated donor hematopoietic stem cell transplant with non-myeloablative regimen at Levine Cancer Institute
- Recipient must have planned post-transplant cyclophosphamide
- Ability to understand and comply with study procedures for entire study duration as determined by physician
You will not qualify if you...
- Recipient of haplo-identical or matched related transplant without a willing donor consenting to participate
- Recipient treated with any investigational drug within 30 days before day -6 of treatment
- Donor of haplo-identical or matched related transplant without a willing recipient consenting to participate
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Levine Cancer Institute
Charlotte, North Carolina, United States, 28204
Actively Recruiting
Research Team
E
Elizabeth Parke
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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