Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
Healthy Volunteers
NCT07377370

Factors Influencing Postoperative Pain After Gingival Graft Harvesting

Led by Universitat Internacional de Catalunya · Updated on 2026-02-04

93

Participants Needed

1

Research Sites

82 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

This prospective cohort study aims to evaluate patient-related, psychological, and clinical factors influencing postoperative pain following gingival graft harvesting from the palate. Consecutive adult patients requiring mucogingival surgery for root coverage or soft tissue augmentation around teeth or dental implants will be recruited at the Clínica Universitària d'Odontologia of Universitat Internacional de Catalunya (Barcelona, Spain). All participants will undergo standardized pre-surgical periodontal care and oral hygiene instruction prior to surgery. Gingival grafts will be harvested from the palate under local anesthesia using a standardized surgical technique. Postoperative management will include analgesic medication, antiseptic rinses, and standardized postoperative instructions. Patient-reported outcomes will be collected using validated questionnaires to assess anticipated pain, postoperative pain, stress, dental anxiety, psychological profile, personality traits, pain catastrophizing, coping strategies, oral health-related quality of life, and analgesic consumption. Postoperative pain and discomfort during eating will be recorded daily for two weeks. Clinical variables, including palatal thickness, graft dimensions, operative time, operator experience, and donor-site wound healing, will also be assessed. The primary outcome is postoperative pain intensity following palatal graft harvesting. Secondary outcomes include operative time, donor-site discomfort, oral health-related quality of life, analgesic consumption, psychological and behavioral factors, and donor-site healing. The results of this study aim to improve understanding of factors associated with postoperative pain and to support individualized patient management in mucogingival surgery.

CONDITIONS

Official Title

Factors Influencing Postoperative Pain After Gingival Graft Harvesting

Who Can Participate

Age: 18Years +
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Patients requiring mucogingival surgery for gingival augmentation or root coverage purposes
  • Systemically healthy individuals aged 18 years or older
  • Healthy periodontal status according to the AAP/EFP definition
  • Full-mouth plaque score (FMPS) and full-mouth bleeding score (FMBS) �3C= 20%
Not Eligible

You will not qualify if you...

  • Pregnancy or lactation
  • Self-reported smoking �3E= 10 cigarettes/day
  • Presence of metabolic or systemic diseases that negatively affect soft tissue healing
  • Use of medications that may interfere with wound healing
  • Chronic pain disorders (e.g., fibromyalgia)
  • Psychiatric diagnoses
  • Regular use of analgesics, antidepressants, anxiolytics, or opioids
  • Allergy to the study medication (Ibuprofen)
  • History of grafting within the past 6 months
  • Ongoing orthodontic therapy

AI-Screening

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Trial Site Locations

Total: 1 location

1

Clínica Universitària d'Odontologia - UIC Barcelona

Barcelona, Sant Cugat Del Valles, Spain, 08195

Actively Recruiting

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Research Team

L

Lory Abrahamian, DDS, MSc, PhD Candidate

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SINGLE_GROUP

Primary Purpose

TREATMENT

Number of Arms

1

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