Actively Recruiting
Familial and Functional Study of Genetic Variants Identified in People With Schizophrenia, Bipolar Disorder, Autism Spectrum Disorder or Resistant Depression
Led by Fondation FondaMental · Updated on 2024-04-23
50
Participants Needed
1
Research Sites
287 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Genetic analyses conducted on patient with psychiatric disorders assessed at the expert centres resulted in the identific action of genetic variants associated with psychiatric disorders (Courtois, 2020). These data require further genetic and functional analyses. The first objective of this study is to investigate the disease-related inheritance of genetic variants in the families of individuals in whom these variants have been identified. The second objective is to explore the functional consequences of disease-associated genetic variants in patients cells and those of their relatives with and without these variants. The present project aims to enrich existing biocollections with DNA from blood or saliva from relatives of patients identified with genetic variants. In addition, we wish to collect hair follicules from patients with identified genetic variants of interest and their family members who wish to participate in the study. These hair samples with SNA will be used to dedifferentiate the isolated cells into induced pluripotent stem cells (IPSCs), and then to differentiate them into cells expressing the gene of interest, such as neurons or astrocytes, or into more complex systems, such as brain organoids.
CONDITIONS
Official Title
Familial and Functional Study of Genetic Variants Identified in People With Schizophrenia, Bipolar Disorder, Autism Spectrum Disorder or Resistant Depression
Who Can Participate
Eligibility Criteria
You may qualify if you...
- For patients: diagnosed with bipolar disorder, unipolar depression, schizophrenia, or autism spectrum disorder according to DSM IV criteria
- Age over 18 years
- Affiliated to the social security system
- Includes patients under guardianship or curatorship
- Patients included in the Fondation FondaMental cohort with genetic analyses indicating need for further study
- Signed consent form
- For relatives: age over 18 years
- Relative of patient included in the Fondation FondaMental cohort
- Includes relatives under guardianship or curatorship
- Signed consent form
- Affiliated to social security
You will not qualify if you...
- Any condition making participation undesirable or compromising protocol compliance
- Persons deprived of liberty
- Inability to understand French
AI-Screening
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Trial Site Locations
Total: 1 location
1
Hopital Albert Chenevier
Créteil, France, 94000
Actively Recruiting
Research Team
S
Stephane JAMAIN, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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