Actively Recruiting
Familial Intrahepatic Cholestasis-related Genes Associated with Disease Susceptibility in Hepato-biliary Cancers
Led by IRCCS Azienda Ospedaliero-Universitaria di Bologna · Updated on 2025-01-16
600
Participants Needed
5
Research Sites
153 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a cross-sectional, multicenter tissue study with an exploratory aim to estimate the prevalence of genetic mutations that predispose individuals to diseases in the context of cholestatic disorders and hepatobiliary neoplasms. It is intended as a hypothesis-generating study for future empirical investigations.
CONDITIONS
Official Title
Familial Intrahepatic Cholestasis-related Genes Associated with Disease Susceptibility in Hepato-biliary Cancers
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of primary liver or biliary tumors (hepatocellular carcinoma, cholangiocarcinoma, hepatocholangiocarcinoma) without obvious chronic liver disease or in cryptogenic chronic liver disease
- Curative treatment by surgical tumor removal or liver transplantation
- Cholestatic chronic liver disease with GGT and/or alkaline phosphatase over 1.5 times normal in two or more tests at least 6 months apart
- History of itching combined with bile acid levels over 10 mmol/l for 6 months or longer
- Written informed consent obtained
You will not qualify if you...
- Other documented chronic liver diseases explaining the symptoms, including primary biliary cholangitis, primary sclerosing cholangitis, IgG4-related cholangiopathy
- Obstructive jaundice excluded by normal bile duct anatomy
- Negative tests for hepatitis B, C, and E viruses
- History of alcohol abuse
- Diagnosed hemochromatosis, Wilson's disease, or alpha-1 antitrypsin deficiency
AI-Screening
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Trial Site Locations
Total: 5 locations
1
IRCCS Azienda Ospedaliero-Universitaria di Bologna - Programma Chirurgia addominale nell'insufficienza d'organo terminale e nei pazienti con trapianto d'organo
Bologna, Bologna, Italy, 40138
Actively Recruiting
2
IRCCS Azienda Ospedaliero-Universitaria di Bologna - UO Chirurgia Epatobiliare e dei Trapianti
Bologna, Bologna, Italy, 40138
Actively Recruiting
3
IRCCS Azienda Ospedaliero-Universitaria di Bologna - UO Gastroenterologia
Bologna, Bologna, Italy, 40138
Actively Recruiting
4
IRCCS Azienda Ospedaliero-Universitaria di Bologna - UO Medicina Interna per il trattamento delle gravi insufficienze d'organo
Bologna, Bologna, Italy, 40138
Actively Recruiting
5
IRCCS Azienda Ospedaliero-Universitaria di Bologna - UO Medicina Interna, malattie epatobiliari e immunoallergologiche
Bologna, Bologna, Italy, 40138
Actively Recruiting
Research Team
G
Giovanni Vitale
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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