Actively Recruiting
Familial Investigations of Childhood Cancer Predisposition
Led by St. Jude Children's Research Hospital · Updated on 2026-04-23
1500
Participants Needed
1
Research Sites
1042 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
NOTE: This is a research study and is not meant to be a substitute for clinical genetic testing. Families may never receive results from the study or may receive results many years from the time they enroll. If you are interested in clinical testing please consider seeing a local genetic counselor or other genetics professional. If you have already had clinical genetic testing and meet eligibility criteria for this study as shown in the Eligibility Section, you may enroll regardless of the results of your clinical genetic testing. While it is well recognized that hereditary factors contribute to the development of a subset of human cancers, the cause for many cancers remains unknown. The application of next generation sequencing (NGS) technologies has expanded knowledge in the field of hereditary cancer predisposition. Currently, more than 100 cancer predisposing genes have been identified, and it is now estimated that approximately 10% of all cancer patients have an underlying genetic predisposition. The purpose of this protocol is to identify novel cancer predisposing genes and/or genetic variants. For this study, the investigators will establish a Data Registry linked to a Repository of biological samples. Health information, blood samples and occasionally leftover tumor samples will be collected from individuals with familial cancer. The investigators will use NGS approaches to find changes in genes that may be important in the development of familial cancer. The information gained from this study may provide new and better ways to diagnose and care for people with hereditary cancer. PRIMARY OBJECTIVE: * Establish a registry of families with clustering of cancer in which clinical data are linked to a repository of cryopreserved blood cells, germline DNA, and tumor tissues from the proband and other family members. SECONDARY OBJECTIVE: * Identify novel cancer predisposing genes and/or genetic variants in families with clustering of cancer for which the underlying genetic basis is unknown.
CONDITIONS
Official Title
Familial Investigations of Childhood Cancer Predisposition
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Individuals with familial cancer defined as: cancer diagnosed under 26 years of age with a relative diagnosed under 51 years; or multiple cancers with one under 26 years; or a known cancer predisposition syndrome; or congenital cancer diagnosed before 6 months; or rare pediatric cancer diagnosed before 26 years
- Biologic relatives of individuals meeting the familial cancer definition, affected or unaffected by cancer
You will not qualify if you...
- Unable or unwilling to provide written informed consent
- Received allogeneic bone marrow transplant without available pre-transplant germline DNA and unwilling to provide a skin sample
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
St. Jude Children's Research Hospital
Memphis, Tennessee, United States, 38105
Actively Recruiting
Research Team
K
Kim E. Nichols, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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