Actively Recruiting
Familial Investigations of Childhood Cancer Predisposition
Led by St. Jude Children's Research Hospital · Updated on 2026-04-23
1500
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research investigates hereditary cancer predisposition by identifying novel genes and genetic variants that may contribute to familial cancer. While hereditary factors are known to cause some cancers, many causes remain unknown. The study focuses on families with cancer clustering, aiming to better understand genetic links to improve diagnosis and care for hereditary cancer. Participants provide blood or saliva samples and medical and family history information. Leftover tumor samples may also be collected when available. Samples are stored in a biorepository and studied using next generation sequencing to detect gene changes. Some participants may provide skin samples if they had bone marrow transplants without available pre-transplant DNA. Participants may be contacted yearly for health and family history updates. During the study, researchers analyze DNA and other biological samples to find mutations linked to cancer. This includes sequencing, genetic and cellular studies, and possibly stem cell analyses. Personal information is removed, and samples remain in the repository for future research. The primary outcome is identifying new cancer predisposing genes, with follow-up of up to 20 years from study start.
CONDITIONS
Brief Title
Familial Investigations of Childhood Cancer Predisposition
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Individuals diagnosed with cancer before age 26 who have at least one first, second, or third degree relative diagnosed with cancer before age 51
- Individuals diagnosed with more than one cancer, with at least one diagnosed before age 26
- Individuals with a known clinical or molecular diagnosis of a cancer predisposition syndrome
- Individuals diagnosed with congenital cancer before 6 months of age
- Individuals diagnosed with a rare pediatric cancer or tumor before age 26
- Biological relatives of affected individuals, whether or not they have cancer
You will not qualify if you...
- Inability or unwillingness to provide written informed consent
- Individuals who received an allogeneic bone marrow transplant without pre-transplant germline DNA available and unwilling to provide a skin sample
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person or at a convenient location for sample collection)
Duration - Initial collection with possible additional collections if needed
Participants provide biological samples such as blood, saliva, or skin to be used for genetic analysis related to cancer predisposition.
1 to 5 visits depending on sample collection needs
Duration - Up to 20 years following study activation
Participants may be contacted about once each year to update their health information and family history.
Approximately annual contacts for updates
Trial Site Locations
Total: 1 location
1
St. Jude Children's Research Hospital
Memphis, Tennessee, United States, 38105
Actively Recruiting
Research Team
K
Kim E. Nichols, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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