Actively Recruiting
Study Investigating Genetic Causes of Familial Cancer in Children and Families to Identify New Predisposing Genes
Led by St. Jude Children's Research Hospital · Updated on 2026-06-17
1500
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying familial cancer in children and their families to discover new genetic causes. This observational study focuses on families with a history of cancer to identify novel cancer-predisposing genes and genetic variants. The study aims to expand understanding of hereditary cancer predisposition by using next generation sequencing NGS technologies and establishing a linked data registry and biological sample repository. Participants provide blood samples, saliva, skin samples when needed, and occasionally leftover tumor or bone marrow samples. These biological specimens are stored in a biorepository and analyzed to detect gene changes potentially responsible for familial cancer. Participants may also be asked yearly for updated health and family history information if they agree to future contact. During the study, researchers collect medical and family histories along with biological samples to perform DNA sequencing and other genetic analyses. Samples are coded to protect identity and stored for current and future research. The primary outcome is identifying new cancer-related genes over up to 20 years. Participation involves sample collection and periodic updates, with ongoing confidentiality and long-term monitoring.
CONDITIONS
Brief Title
Familial Investigations of Childhood Cancer Predisposition
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Individuals diagnosed with cancer before age 26 who have at least one relative diagnosed with cancer before age 51
- Individuals diagnosed with more than one cancer, with at least one diagnosed before age 26
- Individuals with a known clinical or molecular cancer predisposition syndrome
- Individuals with congenital cancer diagnosed before 6 months of age
- Individuals with rare pediatric cancers or tumors diagnosed before age 26
- Biological relatives of individuals meeting the above criteria, regardless of cancer status
You will not qualify if you...
- Inability or unwillingness to provide written informed consent
- Participants who have had allogeneic bone marrow transplantation and lack pre-transplant germline DNA and are unwilling to provide a skin sample
Research Team
K
Kim E. Nichols, MD
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