Actively Recruiting
Family Building Decision Support for Female Adolescent and Young Adult Cancer Survivors
Led by Duke University · Updated on 2026-05-14
48
Participants Needed
1
Research Sites
29 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aims to develop and pilot-test a nurse navigator-delivered behavioral program to support female adolescent and young adult (AYA) cancer survivors in making informed, values-driven family-building decisions after completion of cancer treatment. Female AYA survivors often face fertility impairments, uncertainty about reproductive potential, elevated obstetric risks during pregnancy, and significant emotional distress related to parenthood planning. Currently, few interventions address these post-treatment decision-making needs. The intervention consists of four videoconference sessions that combine personalized, risk-based reproductive health education with coping strategies derived from Acceptance and Commitment Therapy and Patient Activation Theory. A pilot randomized controlled trial will evaluate feasibility, acceptability, and preliminary changes in knowledge, decisional conflict, self-efficacy, and reproductive-health-related distress among 48 participants randomized to the intervention or a survivorship-education control condition. Findings will inform future testing of the intervention's efficacy in a larger clinical trial.
CONDITIONS
Official Title
Family Building Decision Support for Female Adolescent and Young Adult Cancer Survivors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female (biological sex) adolescent and young adult cancer survivor aged 15-39 at diagnosis and 18-39 at enrollment
- Completed cancer treatment with curative intent
- Prior exposure to treatments posing gonadotoxic risk (e.g., alkylating agents, total body irradiation) and/or treatments increasing obstetric risk (e.g., chest radiation, uterine radiation, anthracycline exposure)
- Has not completed family building
- Able to speak and read English
- Willing and able to complete videoconference sessions and surveys
You will not qualify if you...
- Visual, hearing, or cognitive impairment or severe mental illness that would interfere with participation as determined by study staff
AI-Screening
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Trial Site Locations
Total: 1 location
1
Duke Cancer Institute
Durham, North Carolina, United States, 27710
Actively Recruiting
Research Team
S
Smrithi Divakaran, MBBS, MSPH
CONTACT
M
Michael W Willis, BA
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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