Actively Recruiting
FAPi-PET Imaging of in Vivo Fibrosis in Inflammatory Bowel Disease Patients
Led by Dalia Lartey · Updated on 2024-09-19
20
Participants Needed
1
Research Sites
69 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Our main objective is to evaluate the feasibility of 68Ga-FAPi PET/CT in detecting intestinal fibrosis in patients with IBD. To this end, we will determine 68Ga-FAPi uptake in IBD in relation to cellular FAP expression in intestinal biopsies and resection specimens.
CONDITIONS
Official Title
FAPi-PET Imaging of in Vivo Fibrosis in Inflammatory Bowel Disease Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults 18 years or older with confirmed Crohn's disease and gastrointestinal complaints such as diarrhea, bloody or loose stools, abdominal pain, or obstructive symptoms
- Adults 18 years or older with confirmed Crohn's disease and increased CRP (>5 mg/L) and/or fecal calprotectin levels (>250 mg/kg)
- Adults 18 years or older with confirmed Crohn's disease and active disease confirmed by endoscopy (endoscopic SES-CD score >3)
- Adults 18 years or older with confirmed Crohn's disease and active disease confirmed by intestinal ultrasound or MRI (bowel wall thickening, signs of active disease)
- Adults 18 years or older with confirmed ulcerative colitis and active disease confirmed by endoscopy (endoscopic Mayo score 2 2)
- Adults 18 years or older with confirmed ulcerative colitis and active disease confirmed by intestinal ultrasound (bowel wall thickness >3 mm in at least one bowel segment and at least one other pathological ultrasound parameter)
- Adults 18 years or older with confirmed ulcerative colitis and increased CRP (>5 mg/L) and/or fecal calprotectin levels (>250 mg/kg)
You will not qualify if you...
- Pregnant individuals
- Unable to provide informed consent
- History of IBD-related surgeries within the last 5 years
- Diagnosis of colorectal carcinoma
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Amsterdam UMC
Amsterdam, North Holland, Netherlands, 1081 BT
Actively Recruiting
Research Team
D
Dalia A Lartey, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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