Actively Recruiting
FAPI-74 PET/CT in Adults With Fibrosis
Led by Abramson Cancer Center at Penn Medicine · Updated on 2026-02-09
45
Participants Needed
1
Research Sites
158 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This protocol is intended as a basket protocol designed to evaluate the use of Fibroblast Activating Protein (FAP) PET/CT in imaging the presence of fibrosis caused by a variety of medical conditions where fibrosis is believed to lead to pathological effects and poor prognosis.
CONDITIONS
Official Title
FAPI-74 PET/CT in Adults With Fibrosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants must be 21 years of age or older
- Diagnosis or suspicion of fibrosis-inducing medical condition (varies by cohort)
- Head and Neck Cancer Cohort: diagnosed with oropharyngeal squamous cell carcinoma and surgical candidates
- PTLD Cohort: microbiologically confirmed drug-sensitive pulmonary tuberculosis and completed TB treatment within 2 years
- Cardiac Sarcoidosis Cohort: FDG PET/CT scan consistent with active cardiac sarcoidosis and clinical suspicion of cardiac involvement
- Exploratory Cohort: history of known or suspected fibrosis-inducing medical condition
- Participants must be informed of the investigational nature of the study and willing to provide written informed consent
You will not qualify if you...
- Head and Neck Cancer Cohort: not eligible for tissue resection
- PTLD Cohort: rifampin-resistant tuberculosis diagnosis
- History of alternative pulmonary disease
- Use of corticosteroids or systemic investigational agents within 3 months before screening
- Symptoms or signs suggestive of active tuberculosis at pre-screening
- Women of childbearing potential who are pregnant or breastfeeding (negative pregnancy test required before injection)
- Inability to tolerate imaging procedures
- Any medical condition that could compromise safety or participation
- Treatment with agents targeting fibroblast activation protein within 1 month prior to enrollment
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
Research Team
E
Erin Schubert
CONTACT
M
Mary Hansbury
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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