Actively Recruiting
Faricimab + PRP vs. Vitrectomy + Endolaser for Treatment of PDR
Led by Jaeb Center for Health Research · Updated on 2026-01-29
426
Participants Needed
20
Research Sites
312 weeks
Total Duration
On this page
Sponsors
J
Jaeb Center for Health Research
Lead Sponsor
N
National Eye Institute (NEI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This randomized trial will compare treatment strategies for proliferative diabetic retinopathy (PDR). Participants will receive either combination a of faricimab + PRP or vitrectomy + endolaser. The participants will be followed for 3 years. The study will evaluate long-term visual acuity as well as differences in number of injections, procedures, and complications during follow-up (after completion of randomization treatment), and cost.
CONDITIONS
Official Title
Faricimab + PRP vs. Vitrectomy + Endolaser for Treatment of PDR
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 years old or older
- Diagnosis of diabetes mellitus (type 1 or type 2)
- Presence of PDR requiring treatment, confirmed by central reading center
- Best corrected visual acuity 20/100 Snellen equivalent or better (49 letters or more)
You will not qualify if you...
- History of chronic renal failure requiring dialysis or kidney transplant
- Blood pressure above 160/100 (unless controlled below this with medication)
- Pregnant, lactating, or intending to become pregnant within 3 years (for women of child-bearing potential)
- Traction retinal detachment involving the macula in study eye
- Significant vitreous hemorrhage preventing full PRP in study eye
- Significant vitreomacular traction in study eye
- Any prior vitrectomy in study eye
- Prior PRP with 100 or more burns outside the posterior pole in study eye
- Treatment for diabetic macular edema within prior 6 months in study eye
- Intravitreal anti-VEGF for any indication other than DME within prior year in study eye
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 20 locations
1
Retina Associates of Southern California
Huntington Beach, California, United States, 92647
Actively Recruiting
2
Loma Linda University
Loma Linda, California, United States, 92354
Actively Recruiting
3
Florida Retina Consultants
Lakeland, Florida, United States, 33805
Actively Recruiting
4
Ophthalmic Partners of Florida, PA dba Central Florida Retina
Orlando, Florida, United States, 32806
Actively Recruiting
5
Retina Associates of Florida, LLC
Tampa, Florida, United States, 33609
Actively Recruiting
6
Southeast Retina Center, P.C.
Augusta, Georgia, United States, 30909
Actively Recruiting
7
Illinois Retina Associates SC Oak Park Site
Oak Park, Illinois, United States, 60304
Actively Recruiting
8
Midwest Eye Institute
Carmel, Indiana, United States, 46032
Actively Recruiting
9
Wolfe Clinic, P.C.- West Des Moines
West Des Moines, Iowa, United States, 50266
Actively Recruiting
10
Mid-America Retina Consultants, P.A.
Overland, Kansas, United States, 66211
Actively Recruiting
11
University of Kentucky Advanced Eye Care
Lexington, Kentucky, United States, 40508
Actively Recruiting
12
Elman Retina Group, P.A.
Baltimore, Maryland, United States, 21237
Actively Recruiting
13
Boston Medical Center Corporation
Boston, Massachusetts, United States, 02118
Actively Recruiting
14
Joslin Diabetes Center
Boston, Massachusetts, United States, 02215
Actively Recruiting
15
Mayo Clinic
Rochester, Minnesota, United States, 55905
Actively Recruiting
16
Retina Research Institute, LLC
St Louis, Missouri, United States, 63128
Actively Recruiting
17
Retina Associates of Western NY, P.C.
Rochester, New York, United States, 14620
Actively Recruiting
18
Retina-Vitreous Consultants, Inc.
Monroeville, Pennsylvania, United States, 15146
Actively Recruiting
19
Retina Consultants of Texas, PA
Bellaire, Texas, United States, 77401
Actively Recruiting
20
Texas Retina Associates
Lubbock, Texas, United States, 79424
Actively Recruiting
Research Team
C
Cynthia Stockdale
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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