Actively Recruiting

Phase 2
Age: 18Years - 59Years
All Genders
Healthy Volunteers
NCT07487090

Fasted vs. Fed State Exercise

Led by Arkansas Colleges of Health Education · Updated on 2026-03-23

40

Participants Needed

1

Research Sites

99 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Although many medications exist for both heart disease and obesity, cost, lack of access for all people, side effects and the desire for a more natural solution have left many people seeking lifestyle treatments such as exercise. Scientists know that exercise is highly beneficial for heart health. When exercise also produces weight loss, these benefits are much improved. Although using exercise to treat or prevent heart disease / obesity is recommended, not all people respond well. Some see significant weight loss and health improvements while others see little changes. For these reasons, new strategies surrounding the use and design of an exercise program are needed. One such strategy could be performing aerobic exercise before breakfast (fasted exercise). When exercising fasted, food/energy stores are low, and one relies on stored body fat for energy. This may help heart health and weight loss. This has never been tested in a program long enough to see such changes. This study will, for the first time, assess the effects of a 16-week aerobic exercise program performed fasted compared to after eating. Outcomes will include blood fats, blood pressure, fat-burning abilities and weight loss. Starting an exercise program can also make people to eat more. This limits the success of exercise. The study will also evaluate ways fasted exercise could change eating, as it possible that fasted exercise could also cause people to eat more, which would limit weight loss and health improvements.

CONDITIONS

Official Title

Fasted vs. Fed State Exercise

Who Can Participate

Age: 18Years - 59Years
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Aged 18-59
  • Body mass index (BMI) between 25 and 45
  • Healthy enough to exercise
Not Eligible

You will not qualify if you...

  • Taking medications or supplements known to affect energy expenditure
  • Exercising more than once per week currently
  • Actively dieting for weight loss
  • Using weight loss drugs currently
  • History of weight loss surgery
  • Diagnosed with diabetes
  • Diagnosed with heart disease including heart failure, uncontrolled hypertension, uncontrolled hypercholesterolemia, or coronary heart disease

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

1
2
3
+1

Trial Site Locations

Total: 1 location

1

Arkansas Colleges of Health Education Research Institure Health and Wellness Center

Fort Smith, Arkansas, United States, 72916

Actively Recruiting

Loading map...

Research Team

K

Kyle D Flack, PhD

CONTACT

B

Blake Metcalf, DCN

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

Not the Right Trial for You?

Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.

Already have an account? Log in here