Actively Recruiting
Fasting Induced Hypoglycaemia in Anaesthetised Paediatric Patients
Led by Guy's and St Thomas' NHS Foundation Trust · Updated on 2025-12-02
6580
Participants Needed
3
Research Sites
41 weeks
Total Duration
On this page
Sponsors
G
Guy's and St Thomas' NHS Foundation Trust
Lead Sponsor
E
Evelina London Children's Charity
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are studying the risk and definition of hypoglycemia in children undergoing elective procedures under general anesthesia. The current fasting guidelines require patients to fast for set times before anesthesia, which may increase hypoglycemia risk in young children due to their immature metabolism. The study aims to better define hypoglycemia in this context and identify risk factors in pediatric patients, especially those under 2 years old. The research involves observing children aged 1 month to 18 years who are scheduled for elective procedures with general anesthesia. Fasting times follow traditional guidelines, and blood glucose levels are monitored immediately or within five minutes after anesthesia induction to assess hypoglycemia. The study includes various elective cases such as day surgeries, colonoscopies, MRI, radiology, and dental procedures requiring anesthesia. Participants will have their blood glucose and ketone levels measured around the time of anesthesia induction to evaluate hypoglycemia thresholds and risks linked to age and weight. Data on blood sugar levels and ketones will help establish a clinical definition of hypoglycemia and its frequency in fasting children. The study is observational, and no changes to standard care are made. The total participation time varies depending on the scheduled procedure and monitoring.
CONDITIONS
Brief Title
Fasting Induced Hypoglycaemia in Anaesthetised Paediatric Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Children aged 1 month to 18 years with American Society of Anesthesiology (ASA) score 1 to 3
- Scheduled for elective procedures involving general anesthesia during the study period
- Includes day cases and patients admitted the night before for bowel preparation prior to elective colonoscopy
- Planned expedited cases in ASA 1 or 2 children, such as nail bed repairs, lacerations, foreign body removal, and simple fractures requiring anesthesia
- MRI, radiology, and dental cases with general anesthesia included
You will not qualify if you...
- Children younger than 1 month old
- Procedures done only under oral sedation or local anesthesia
- Children with ASA status 4 or 5
- Children with endocrine or metabolic disorders affecting glucose control, including diabetes, glycogen storage disease, and other listed metabolic conditions
- Emergency and oncology procedures
- Critically ill children requiring anesthetic care in emergency or intensive care settings
- Children receiving glucose-containing intravenous solutions or total parenteral nutrition before surgery
- Children on systemic steroid treatment (oral or intravenous)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Less than 1 day
Participants undergo measurements of blood glucose and ketone levels immediately after anesthesia induction to assess fasting induced hypoglycemia.
1 visit (in-person) during anesthesia induction
Duration - Up to the duration of the elective procedure and immediate recovery period
Participants are observed for risk factors such as age and weight related to hypoglycemia after the initial measurements.
No additional visits beyond procedure
Trial Site Locations
Total: 3 locations
1
Royal Devon University Healthcare NHS Foundation Trust
Exeter, Devon, United Kingdom, EX2 5DW
Actively Recruiting
2
Moorfields Eye Hospital
London, United Kingdom, EC1V 2PD
Completed
3
Evelina London Children's Hospital
London, United Kingdom, SE17EH
Actively Recruiting
Research Team
B
Benjamin Blaise, MD PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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