Actively Recruiting
Fatty Acid Modulation of Brain Function in Older Adults
Led by University of Vermont · Updated on 2025-09-17
60
Participants Needed
1
Research Sites
237 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
In this crossover study, the investigtors will administer two experimental diets in a random order for one week, and each experimental diet will be preceded by a one-week, low fat control diet for a total four-week study period. The goal is to study how the fatty acid content of the diet affects brain functioning in healthy adults aged 65-75 years. One experimental diet will have a high palmitic acid (PA)/oleic acid (OA) ratio (HPA), typical of the North American diet. The other experimental diet will have a low PA/OA ratio (HOA), typical of the Mediterranean Diet. All allowed food and drink (except water) will be provided by the investigative team, and compliance will be enhanced by constant, intense dietary surveillance by a registered dietitian.
CONDITIONS
Official Title
Fatty Acid Modulation of Brain Function in Older Adults
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Men and women aged 65 to 75 years
- Normal cognition as assessed by study cognitive tests
- Healthy with body mass index (BMI) between 20 and 40 kg/m2
You will not qualify if you...
- Significant cognitive or behavioral impairment or use of medications for these conditions
- Hormone replacement therapy within the past 3 months
- Hyper-androgenic conditions
- HbA1C 7.5% or higher or fasting plasma glucose 130 mg/dL or higher
- Type 2 diabetes treated with medications other than metformin
- Use of nicotine or intake of caffeine or alcohol during the study
- Habitual fat intake less than 25% of calories or strict vegetarian diet
- Sleep apnea requiring continuous positive airway pressure at night
- Lung, heart failure or treatment, liver, kidney disease, cancer, or other medical disorders causing inflammation or cognitive problems
- Actively training for athletic events or competitive sports
- Allergy or intolerance to any study-provided foods
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University of Vermont
Burlington, Vermont, United States, 05401
Actively Recruiting
Research Team
J
Julie Dumas, Ph.D.
CONTACT
J
Jenna Makarewicz, B.S.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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