Actively Recruiting
Fatty Acid Synthase Inhibition in Castration Refractory Prostate Cancer
Led by Wake Forest University Health Sciences · Updated on 2026-04-13
50
Participants Needed
2
Research Sites
364 weeks
Total Duration
On this page
Sponsors
W
Wake Forest University Health Sciences
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this research study is to find out what effects (good and bad) omeprazole and cabazitaxel, or omeprazole and docetaxel, has on participants and their condition. Investigators believe omeprazole may help the other medications work.
CONDITIONS
Official Title
Fatty Acid Synthase Inhibition in Castration Refractory Prostate Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients must have castrate refractory prostate cancer with prior docetaxel treatment used in the castrate refractory setting
- Evidence of cancer progression by prostate cancer working group 3 criteria
- Age 18 years or older
- ECOG performance status of 0, 1, or 2
- Life expectancy greater than 2 months
- Men must agree to use adequate contraception or abstinence before and for 3 months after treatment
- Ability to understand and sign informed consent
- Adequate organ and marrow function: absolute neutrophil count >1,200/mcL, platelets >75,000/mcL; bilirubin within normal limits; AST/ALT less than 2.5 times upper limit; creatinine less than 2.5 times upper limit
You will not qualify if you...
- Receiving any other investigational agents
- History of allergic reactions to omeprazole, taxane therapy, or similar compounds
- Uncontrolled illnesses such as active infection, symptomatic heart failure, unstable angina, cardiac arrhythmia, or psychiatric/social issues limiting study compliance
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
W.G. Bill Hefner VA Medical Center
Salisbury, North Carolina, United States, 28144
Actively Recruiting
2
Wake Forest Baptist Comprehensive Cancer Center
Winston-Salem, North Carolina, United States, 27157
Actively Recruiting
Research Team
S
Study Coordinator
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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