Actively Recruiting
FAXAGE: Fasting And Exercise To Slow Aging In Humans
Led by University of Copenhagen · Updated on 2026-01-28
240
Participants Needed
1
Research Sites
882 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
FAXAge is a randomized controlled trial investigating the effects of fasting and exercise on human aging. 240 participants over the age of 65 will be divided into 4 groups - an exercise group, a fasting group, a combined exercise and fasting group and a control group. The intervention will last for one year, and tests of biomarkers of aging will be performed at baseline, after 3 months, 6 months and at the end of the intervention. A reference group of participants over the age of 20 equally distributed by age and sex will be used to train an algorithm for determination of biological age. The study will include both physical, molecular and digital biomarkers including DNA-methylation, VO2max, body composition and face- and voice-age. The main outcome of the project is DNA-methylation age at week 52. Secondary outcomes are the rest of the tested biomarkers at week 52. It is hypothesised that the intervention groups will have similar superior benefits after the 52 weeks of intervention.
CONDITIONS
Official Title
FAXAGE: Fasting And Exercise To Slow Aging In Humans
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed and dated informed consent provided
- Willingness to comply with all study procedures and be available for the entire study duration
- Age over 20 years
- Good general health with at most one well-managed chronic disease
- Non-smoker
You will not qualify if you...
- Unable or unwilling to follow the time-restricted feeding schedule
- Unable or unwilling to perform the prescribed physical exercise
- Participation in another investigational drug or intervention study within the past year
- More than one hour per week of systematic strenuous exercise or strength training
- Currently practicing time-restricted eating habits
- Severe or uncontrolled medical conditions such as active cancer, uncontrolled diabetes, severe lung or heart disease
- Having more than one well-managed chronic disease
- Smoking
- Use of systemic glucocorticoids, androgens, or antiandrogens
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University of Copenhagen
Copenhagen, Copenhagen N, Denmark, 2200
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
4
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