Study of Fibrobronchoscopy and Probe Aspiration for Aspiration Pneumonia Treatment in the Emergency Department
Led by Azienda Ospedaliero-Universitaria Careggi · Updated on 2024-07-22
100
Participants Needed
1
Research Sites
4 weeks
Total Duration
AI-Summary
What this Trial Is About
This observational pilot study focuses on adult patients diagnosed with aspiration pneumonia who require aspiration of secretions or ingesta in the Emergency Department. The study aims to evaluate and compare the usefulness and adverse events of two aspiration methods laryngotracheal aspiration with a probe and aspiration using fibrobronchoscopy. Researchers will create a registry to collect patient data and assess clinical outcomes related to these procedures.
The study involves two main procedures. The first is laryngotracheal aspiration using a blind probe, where a soft catheter is inserted through the nostril to suction secretions from the larynx and trachea in cycles lasting 3-5 seconds. The second procedure uses a bronchoscope inserted through the nostril or mouth to visually inspect the airways and aspirate secretions intermittently to avoid hypoxia, also in 3-5 second cycles. These procedures are performed in the Emergency Department as determined by the attending physician.
Participants will be monitored for various outcomes, including length of hospital stay up to three months and mortality within 30 days of Emergency Department admission. Respiratory parameters, rates of non-invasive ventilation or intubation, admission to intensive or high dependency care units, and procedure-related complications will also be recorded. The total study duration is three years, starting after ethical approval, during which clinical data and patient outcomes will be closely observed.
CONDITIONS
Brief Title
FBS-ASaP: Fibrobronchoscopy in ASpiration Pneumonia in the Emergency Department
Research Team
L
Lorenzo Pelagatti, Dr
P
Pelagatti Lorenzo, Dr
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match. Sign up to get personalized trial recommendations delivered to your inbox.
Diagnosed with aspiration pneumonia requiring secretion or ingesta aspiration in the Emergency Department
Have at least one of the following: radiological evidence of pneumonia, clinical diagnosis of aspiration pneumonia, presence of secretions in upper airways, respiratory distress in a patient with swallowing difficulties, or need for oxygen therapy or increased oxygen in patients already on home oxygen
You will not qualify if you...
Lack of consent
Under 18 years of age
Pregnancy
Bleeding disorders
Malignant cardiac arrhythmias such as ventricular tachycardia or advanced AV block (excluding first-degree AV block)
Severe airway obstruction
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Aspiration Procedure in the Emergency Department
Duration - Single day during Emergency Department visit
Participants undergo either laryngotracheal aspiration using a blind probe or aspiration using fibrobronchoscopy to remove secretions from the airways.
1 procedure visit (in-person)
Monitoring
Duration - Up to 3 months
Participants are observed for respiratory parameters, procedure-related complications, and outcomes including hospital stay length and mortality.
Follow-up assessments including measurements immediately and 30 minutes after the procedure, and monitoring up to 3 months
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
Similar Trials
Evaluating AI-Driven Autonomous Registration
in Robotic Bronchoscopy for Lung Nodule Localization
Study of Chewing Gum and Cold Water Gargle to Reduce Sore Throat and Swallowing Difficulty After Bronchoscopy
Study to Develop and Validate Classification and Prediction Models for Difficult Awake Tracheal Intubation Using Flexible Bronchoscopes
Study of Lung and Nasal Fluid and Tissue Samples to Understand Respiratory Infection Risks in Healthy Volunteers and Patients
Study of Fibrobronchoscopy and Probe Aspiration for Aspiration Pneumonia Treatment in the Emergency Department
Study of Ultrasound and Acetaminophen Tests to Measure Stomach Emptying in Children Ages 2 to 18 Undergoing Surgery
Using Gastric Ultrasound to Guide Airway Management in Adults Taking GLP-1 Receptor Agonists Undergoing Scheduled Surgery
Comparing Prucalopride and Famotidine to Treat Aspiration Symptoms in Children and Young Adults with Neurologic Impairment and Digestive Motility Issues
Study Comparing Multi-Patient CT-Derived Digital Twin Anatomical Variability Training Versus Uniform Simulation Models to Improve Early Bronchoscopy Skills in Novice Trainees
Robotic-Assisted Bronchoscopy Using Shape-Sensing Technology to Diagnose Peripheral Lung Nodules in Adults in Korea
Have more questions? Get in touch with our team for quick support
Published Research Related To This Trial
Fibrobronchoscopy versus laryngotracheal aspiration for bronchial toileting in patients with aspiration pneumonia in the emergency department. FBS-ASaP prospective case-control study.
Lorenzo Pelagatti, Alessio Montalbetti, Gabriele Viviani...