Actively Recruiting
Fear and Avoidance in PTSD Patients
Led by The University of Texas Health Science Center, Houston · Updated on 2026-05-05
300
Participants Needed
1
Research Sites
329 weeks
Total Duration
On this page
Sponsors
T
The University of Texas Health Science Center, Houston
Lead Sponsor
N
National Institute of Mental Health (NIMH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this research study is to study how the brain learns to avoid certain stimuli or situations using an experimental paradigm. The big goal is to measure brain responses and subject's feelings and expectations when they are learning to actively avoid experimental stimuli, and how fear extinction learning and monetary cost can change how and when subjects are to avoid.
CONDITIONS
Official Title
Fear and Avoidance in PTSD Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 to 70 years of age
- Female or male
- For PTSD group: diagnosis of current PTSD
- For trauma-exposed healthy controls (TEHC): no current psychiatric disorders and history of trauma exposure
- For healthy controls (HC): no current psychiatric disorders and no history of trauma exposure
- Willing and able to provide informed consent
You will not qualify if you...
- History of neurologic disease such as tic disorder
- Current significant suicidal thoughts, plans, or behavior in past 6 months
- History of seizure or significant head trauma
- History of serious psychiatric diagnoses
- Use of neuroleptics within one year prior to study
- Current substance use (positive urine toxicology for any substance except THC) unless negative at experimental visit
- Pregnancy
- Metallic implants or devices incompatible with MRI
- High risk of adverse emotional or behavioral reactions or inability to understand study procedures or consent
- Additional for TEHC and HC groups: current psychiatric diagnosis
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
UTHealth Houston
Houston, Texas, United States, 77054
Actively Recruiting
Research Team
M
Mohammed Milad, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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