Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
NCT07339462

Feasibility and Acceptability of an Intervention to Support People With Severe Mental Illness in South Africa

Led by University of KwaZulu · Updated on 2026-01-14

86

Participants Needed

1

Research Sites

56 weeks

Total Duration

On this page

Sponsors

U

University of KwaZulu

Lead Sponsor

C

Columbia University

Collaborating Sponsor

AI-Summary

What this Trial Is About

Despite commendable progress in developing mental health systems in low-and-middle income countries, critical gaps remain, particularly the development of community-based systems of support for people living with severe mental illness (SMIs). This application will pilot a co-developed health system strengthening intervention programme in a South African district in order to determine its feasibility, appropriateness and limited efficacy in reducing readmission following discharge from acute psychiatric hospitalization. By generating preliminary data on the real-world implementation of a co-developed programme in low-resource contexts in South Africa, this application seeks to build on an existing foundation of research partnerships and local government collaboration to develop a transitional support intervention that could yield significant and tangible impacts on people living with SMIs in low-resource communities.

CONDITIONS

Official Title

Feasibility and Acceptability of an Intervention to Support People With Severe Mental Illness in South Africa

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Adults aged 18 years and above
  • Currently admitted to a psychiatric ward for acute psychiatric treatment with ICD diagnoses including schizophrenia, delusional disorders, mood disorders with psychosis, bipolar disorder with psychotic symptoms, or severe depressive episodes with psychotic symptoms
  • Determined by psychiatrist to be ready for discharge to community settings
  • Willing and able to participate in the intervention programme
  • Resides with a caregiver such as a family or household member
  • Resides within the geographic boundaries of uMgungundlovu district
Not Eligible

You will not qualify if you...

  • Under 18 years of age
  • Active suicidal thoughts
  • Primary diagnosis of substance abuse or dependence
  • Diagnosed personality disorders
  • Serious cognitive or sensory impairments preventing informed consent or reliable assessment
  • Does not reside with a caregiver
  • Does not reside within the uMgungundlovu district

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Msunduzi Local Municipality

Pietermaritzburg, KwaZulu-Natal, South Africa, 3201

Actively Recruiting

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Research Team

A

André Janse van Rensburg, PhD

CONTACT

T

Tasneem Kathree, PhD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

HEALTH_SERVICES_RESEARCH

Number of Arms

2

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