Outpatient Treatment Using Chest Drain and Talc Pleurodesis for Malignant Pleural Effusion Study to Improve Quality of Life and Manage Breathlessness in Patients

What this Trial Is About

Researchers are investigating a new way to treat patients with malignant pleural effusion, a condition where fluid builds up around the lungs causing breathlessness. The study aims to see if talc pleurodesis, a procedure to stop fluid buildup that usually requires hospital stay, can be safely done on an outpatient basis to improve quality of life. The study also collects patient feedback on the acceptability of this approach. Participants will have a chest drain inserted on the first day to remove fluid using a standard underwater seal bottle. The drain is clamped and opened repeatedly to remove fluid throughout the day before being connected to an ambulatory bag for the patient to go home. On the second day, fluid output is assessed, and if appropriate, talc slurry with lidocaine is instilled to prevent fluid return. The drain remains connected to the ambulatory bag as patients return home. On the third day, further fluid drainage and chest x-rays determine if the drain can be removed and the treatment completed. During the study, patients complete brief questionnaires about breathlessness, chest pain, and satisfaction with the procedure at multiple times on days 1 to 3 and again at day 30. Researchers will monitor the success of delivering the ambulatory talc pleurodesis protocol, patient satisfaction, and safety through chest x-rays and follow-up. The entire treatment and observation span about five days with ongoing follow-up after completion.

Feasibility of Ambulatory Talc. Pleurodesis