Actively Recruiting
Feasibility Assessment of Cardiovascular Endurance Training for the Symptomatic Improvement of Irritable Bowel Syndrome Patients With a Sedentary and Non-active Lifestyle.
Led by Universitair Ziekenhuis Brussel · Updated on 2026-05-06
30
Participants Needed
1
Research Sites
324 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This exploratory study's primary objective is the changes of irritable bowel syndrome (IBS) symptom severity by cardiovascular endurance training (CET) in relation to the baseline sedentary or non-active lifestyle. Secondary endpoints focus on the mechanisms associated with these changes. These mechanisms relate to dietary adaptations, changes in anxiety, depressive comorbidity, somatisation, alterations in the gut microbiome or metabolome, body composition and measures of cardiovascular fitness. Virtually all IBS guidelines mention lifestyle modifications as a management option. Research on the role of physical activity remains underassessed as compared to the other interventions. Therefore, an exploratory proof-of-concept study will investigate the influence of regular physical exercise on symptoms in a small group of IBS patients. This study will gather data on putative underlying mechanisms related to dietary factors, faecal microbiome and metabolome, mental well-being, body composition and cardiovascular fitness.
CONDITIONS
Official Title
Feasibility Assessment of Cardiovascular Endurance Training for the Symptomatic Improvement of Irritable Bowel Syndrome Patients With a Sedentary and Non-active Lifestyle.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 18 - 60 years
- Diagnosis of irritable bowel syndrome based on ROME IV criteria
- Moderate symptom severity with IBS-Symptom Severity Scale above 175
- Sedentary lifestyle with sitting time over 8 hours per day
- Physically inactive with less than 150 minutes of exercise per week according to the IPAQ score
You will not qualify if you...
- Cardiorespiratory disorders that limit participation in physical exercise
- Suspicion or diagnosis of organic disorders other than IBS
- Known inflammatory bowel disease
- Known intestinal motility disorder
- Alcohol use over 14 units per week or other substance abuse
- Active psychiatric disorders
- Systemic or autoimmune disorders affecting the gastrointestinal system
- Prior abdominal surgery except appendectomy or cholecystectomy over 6 months ago
- Previous cancer diagnosis except basocellular carcinoma
- Current chemotherapy treatment
- Gastroenteritis within the past 8 weeks
- Changes in diet within the past 8 weeks
- Use of dietary supplements unless stable for over 8 weeks
- Use of antibiotics, pre-, pro-, or post-biotics within past 8 weeks
- Use of neuromodulators unless stable dose for over 12 weeks
- Use of spasmolytic agents, opioids, loperamide, gelatine tannate, or mucoprotectants within past 8 weeks
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
UZ Brussel
Jette, Belgium, 1090
Actively Recruiting
Research Team
S
Sébastien Kindt
CONTACT
V
Virgini Van Buggenhout
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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