Actively Recruiting
Feasibility of Circulating Tumour DNA (ctDNA) Analysis Using Automated Capillary Blood Sampling
Led by Erasmus Medical Center · Updated on 2026-01-06
35
Participants Needed
1
Research Sites
102 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this observational study is to investigate whether circulating tumor-derived DNA (ctDNA) can be reliably detected and analyzed in blood obtained through automated capillary sampling in adult patients (≥21 years) with colorectal liver metastases (CRLM). The main question it aims to answer is: * Can ctDNA be detected in small volumes of capillary blood collected using an automated sampling device? * Do ctDNA levels measured in capillary blood agree with those measured in venous blood from the same patients? Researchers will compare ctDNA measurements from capillary blood to those from venous blood (reference standard) to see if capillary sampling provides reliable results for ctDNA analysis. Participants will: * Provide a small blood sample through automated capillary collection. * Provide a venous blood sample during the same study visit for comparison.
CONDITIONS
Official Title
Feasibility of Circulating Tumour DNA (ctDNA) Analysis Using Automated Capillary Blood Sampling
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 21 years
- Histologically confirmed metastatic colorectal adenocarcinoma
- Currently diagnosed with progressive colorectal liver metastases (CRLM)
- Signed informed consent to participate in the study
You will not qualify if you...
- Patients responding to chemotherapy treatment
- Illiteracy or insufficient proficiency in the Dutch language
- History of skin infection after venipuncture or intravenous line requiring antibiotics or hospitalization
- History of immunodeficiency or current use of immunosuppressants
- History of blood-borne infections such as HIV, hepatitis, or viral hemorrhagic fever
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Erasmus MC University Medical Center
Rotterdam, South Holland, Netherlands, 3015 GD
Actively Recruiting
Research Team
M
Mirthe Ubink, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here