Feasibility of Deep Inspiratory Internal Jugular Vein Variability in Guiding Preoperative Fluid Replacement: A Prospective, Randomized Controlled Study

What this Trial Is About

Researchers are investigating whether using the variability of the internal jugular vein during deep inspiration can guide fluid infusion before anesthesia to reduce the risk of low blood pressure caused by propofol. This prospective, randomized controlled study compares this method against conventional fluid infusion techniques in adults aged 60 to 80 undergoing surgery. The study aims to assess the feasibility of using ultrasound measurements to direct preoperative fluid replacement safely. Participants receive fluid infusion guided by the internal jugular vein variability based on the 421 fluid replacement principle or conventional fluid infusion at a rate of 0.2 ml/kg/min for 15 minutes before anesthesia induction. Propofol is infused with a target-controlled concentration of 4 bcg/ml, and blood pressure changes within three minutes after induction are monitored. The study includes two groups: one with variability-guided fluid replacement and one with conventional fluid replacement. During the study, ultrasound is used to record breathing cycles to calculate vein variability, and arterial blood pressure is closely observed after propofol administration. Researchers monitor the incidence of a 20% drop in blood pressure as the primary outcome over one year. The trial requires surgery with radial artery puncture and careful monitoring of anesthesia induction effects. Participation lasts through the preoperative fluid infusion, anesthesia induction, and immediate monitoring periods.

Feasibility of Deep Inspiratory Internal Jugular Vein Variability in Guiding Preoperative Fluid Replacement