Evaluating the Effects of a Mediterranean Diet on Juvenile Arthritis and Gut Health in Children Ages 8 to 18

What this Trial Is About

Researchers are studying children aged 8 to 18 with juvenile arthritis to see if a diet based on the Mediterranean Diet can improve their arthritis symptoms and gut health. This trial focuses on how changes in the gut microbiome, the community of bacteria and other organisms in the intestines, might influence the immune system and disease activity. The purpose is to explore if this diet intervention is feasible and helpful for children with arthritis and to prepare for a larger future study. Participants will follow a Mediterranean Diet rich in plant foods such as unrefined cereals, fruits, vegetables, and extra-virgin olive oil, with moderate poultry, dairy, eggs, and low sweets and red meats intake. This diet will be followed for 8 weeks, with an option to continue for an additional 4 weeks. During the study, stool and blood samples will be collected at the start, 8 weeks, and 12 weeks. Participants will also complete questionnaires about their diet, lifestyle, and health, and undergo clinical assessments of their arthritis. Children enrolled will provide samples and information at three points to track changes in their gut microbiome, disease activity, functional status, quality of life, and inflammation markers. Researchers will also monitor diet adherence, tolerability, nutrient intake, sleep quality, physical activity, and medication use. This study will last up to 12 weeks, helping to determine if a larger, multinational study can be done to confirm the effect of diet on juvenile arthritis outcomes.

Feasibility of a Diet Intervention for Juvenile Arthritis