Actively Recruiting
Feasibility and Efficacy of Attentional-Control Training in Sickle Cell Disease
Led by Children's National Research Institute · Updated on 2025-01-10
20
Participants Needed
1
Research Sites
153 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Children with sickle cell disease (SCD) exhibit significantly reduced cognitive functioning (often difficulties with attention) compared to peers and siblings without SCD. EndeavorRx (Akili Interactive Labs: Boston, MA) is an FDA-approved home-based, electronic attentional-control training program designed to treat attention problems in youth. Users access EndeavorRx on a tablet device for 25-30 minutes each day, 5 days per week, for 4 weeks. The program involves training in a game-like environment that repeatedly challenges attentional-control abilities and adapts to user performance, becoming more difficult over time as performance improves. This pilot study is examining the feasibility, acceptability, and preliminary efficacy of EndeavorRx in a sample of 20 children with SCD ages 8-16 who are being treated with chronic blood transfusion therapy.
CONDITIONS
Official Title
Feasibility and Efficacy of Attentional-Control Training in Sickle Cell Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of sickle cell disease
- Age between 8 and 16 years
- Receiving monthly blood transfusions consistently for at least 3 months
- T-score above the 75th percentile for Omission Errors on the Conners' Continuous Performance Test, 3rd Edition (CPT-3) or for the Inattention subscale of the ADHD Rating Scale, Fifth Edition (ADHD-RS-V)
You will not qualify if you...
- Estimated Intelligence Quotient below 70
- Motor, visual, or auditory impairment that prevents computer use
- Known mental health diagnosis that precludes or takes priority over cognitive training
- History of photosensitive seizures
- Insufficient English fluency
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Children's National Hospital
Washington D.C., District of Columbia, United States, 20010
Actively Recruiting
Research Team
S
Steven J Hardy, Ph.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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