Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
NCT05409573

Feasibility of End-tidal Oxygen Concentration Monitoring During Preoxygenation for Intubation in the Intensive Care Unit.

Led by Centre Hospitalier Régional d'Orléans · Updated on 2026-01-29

30

Participants Needed

1

Research Sites

257 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Intubation is a common procedure in the intensive care unit. Hypoxemia is the most frequent complication of this procedure. Monitoring the end-tidal of oxygen is recommended in operating room (OR). End-tidal of oxygen (EtO2) \>90% is an indication of a correct preoxygenation. This monitoring is not used in routine in intensive care unit (ICU). There is no recommendation on the monitoring of end-tidal of oxygen in intensive care unit. In practice, clinicians use pulsed oxygen saturation (SpO2) to determine whether the patient is sufficiently preoxygenated. However, this parameter is not a good indicator of a correct preoxygenation. In the OR, patients are compliant during the preoxygenation period and the measure of EtO2 with the face mask monitor is considered reliable because i) mask leakage is minimal and ii) the patient can breathe slowly and regularly. Theses conditions are not available in critical ill patients requiring emergency intubation. EtO2 measured on the facemask may not reflect true EtO2. This concern about the reliability of EtO2 measurement via the facemask justifies that we conduct a study to compare EtO2 measured on a facemask (facemask EtO2) to EtO2 measured in pharynx (via e nasopharyngeal catheter). The aim of this study is to determine whether the measurement of EtO2 on facemask is reliable in patients in ICU.

CONDITIONS

Official Title

Feasibility of End-tidal Oxygen Concentration Monitoring During Preoxygenation for Intubation in the Intensive Care Unit.

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age 18 years or older
  • Need for intubation in ICU due to acute respiratory failure defined by respiratory rate 25 25/min or clinical signs of respiratory distress
  • Hypoxemia defined as oxygen requirement 25 15L/min or FiO2 2580% to maintain SpO2 2592% or a PaO2/FiO2 ratio <100 mmHg
  • Preoxygenation performed by noninvasive ventilation
Not Eligible

You will not qualify if you...

  • Intubation for cardiac arrest
  • EtO2 monitoring not available
  • Pulsed oxygen saturation monitoring specific for the study not available
  • Preoxygenation by high-flow nasal oxygen therapy or bag-mask ventilation
  • Allergy to lidocaine (for local nasal anesthesia)
  • Patient not affiliated or excluded from social protection
  • Patient under legal protection such as minors, pregnant or breastfeeding women, or persons deprived of liberty by court or administrative decision
  • Previously included in the study

AI-Screening

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Trial Site Locations

Total: 1 location

1

CHR d'ORLEANS

Orléans, France

Actively Recruiting

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Research Team

M

Mai-Anh NAY, PH

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SINGLE_GROUP

Primary Purpose

OTHER

Number of Arms

1

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