Actively Recruiting
Feasibility of Reducing Respiratory Drive Using the Through-flow System
Led by University Health Network, Toronto · Updated on 2024-12-11
15
Participants Needed
1
Research Sites
86 weeks
Total Duration
On this page
Sponsors
U
University Health Network, Toronto
Lead Sponsor
U
Unity Health Toronto
Collaborating Sponsor
AI-Summary
What this Trial Is About
Mechanical ventilation can lead to diaphragm and lung injury. During mechanical ventilation, the diaphragm could be completely rested or it could be overworked, either of which may cause diaphragm injury. Mechanical stress and strain applied by mechanical ventilation or by the patient's own respiratory muscles can also cause injury to the lungs. Diaphragm and lung injury are associated with increased morbidity and mortality. Throughflow is a novel system that can reduce dead space without the need to increase the tidal ventilation, reducing the ventilatory demands and respiratory drive.
CONDITIONS
Official Title
Feasibility of Reducing Respiratory Drive Using the Through-flow System
Who Can Participate
Eligibility Criteria
You may qualify if you...
- PaO2/FiO2 less than or equal to 300 at time of screening
- Oral endotracheal intubation with tube size 7.5 or 8.0 and receiving invasive mechanical ventilation
- Bilateral airspace opacities visible on chest X-ray or chest CT scan
You will not qualify if you...
- Contraindication to esophageal catheterization such as upper gastrointestinal surgery within the last 6 weeks or bleeding esophageal/gastric varices
- Intubation for traumatic brain injury or stroke
- Suspected or diagnosed intracranial hypertension
- Expected to be taken off mechanical ventilation within 24 hours
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University Health Network
Toronto, Ontario, Canada, M5G 2N2
Actively Recruiting
Research Team
R
Rongyu ( Cindy) Jin
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
PREVENTION
Number of Arms
1
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