Actively Recruiting
Feasibility, Safety and Efficacy of a Predominantly Plant-based Diet in an Asian Population With Chronic Kidney Disease
Led by Changi General Hospital · Updated on 2026-04-22
40
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the feasibility, safety, and potential benefits of a predominantly plant-based diet in adults with Stage 3 or 4 chronic kidney disease (CKD) in an Asian population. This two-year follow-up, single-center, open-label study aims to understand how well patients can adhere to a diet with at least 50% of protein coming from plant sources and its effects on kidney function and nutritional status. The study is sponsored by Changi General Hospital and includes monitoring of biochemical markers and quality of life. Participants will be assigned based on preference to either a plant-based diet intervention group receiving personalized advice and educational materials from a renal dietitian or a control group receiving general CKD dietary advice without specific guidance on plant protein intake. Both groups will have dietitian counseling and regular follow-up. Assessments occur every six months, focusing on kidney function, serum potassium, nutritional markers, and other biochemical parameters. During the study, participants will complete questionnaires and food frequency records to measure diet adherence and quality of life. Researchers will monitor safety by tracking hyperkalemia incidence and evaluate benefits such as acidosis improvement. Exploratory outcomes include the impact on CKD progression, nutritional deficiencies, and other CKD-related biochemical changes. The study lasts for two years with regular evaluations to collect these data.
CONDITIONS
Brief Title
Feasibility, Safety and Efficacy of a Predominantly Plant-based Diet in an Asian Population With Chronic Kidney Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 21 to 79 who can give consent
- Diagnosed with Stage 3 or 4 chronic kidney disease (eGFR 15-60 ml/min/1.72m2 for the past 6 months)
- Willing to see a dietitian and follow either a standard CKD diet or a predominantly plant-based CKD diet
- On maximum tolerated dose of ACE inhibitors or ARB as determined by a renal physician
- Able to provide informed consent
You will not qualify if you...
- Transplant patients
- Pregnant or lactating patients
- Patients on any special diet (including long-term vegans or vegetarians) for at least 1 month prior to recruitment
- Age under 21 or 80 and above
- Those who have previously seen a dietitian for CKD
- Patients with severe ischemic heart disease, decompensated liver cirrhosis, malabsorptive diseases, or malignancy
- Patients with BMI less than 18.5 or greater than 40
- Patients with glomerulonephritis, genetic kidney disease, or polycystic kidney disease
- Baseline serum potassium 5.0 mmol/L or above
- Patients unable to modify their diet due to socio-economic issues
- Patients with acute kidney injury in the past 6 months prior to study (unstable renal disease)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 year
Participants receive personalized dietary advice from a renal dietitian to follow either a predominantly plant-based CKD diet or a standard CKD diet to help manage chronic kidney disease.
Regular visits with a dietitian throughout the 1-year period
Trial Site Locations
Total: 1 location
1
Changi General Hospital
Singapore, Singapore, 529889
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here