Actively Recruiting
Feasibility and Safety of Ketamine for Suicidal Patients in the Emergency Department
Led by Lindsay Maguire, MD · Updated on 2026-04-15
50
Participants Needed
2
Research Sites
152 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
There is currently no readily available pharmacologic intervention for suicidal ideation, a true psychiatric emergency, in the Emergency Department (ED). Investigators aim to trial low-dose, intravenous ketamine, a drug with well-established use in treatment-resistant depression, for patients who present to the ED with suicidal ideation.
CONDITIONS
Official Title
Feasibility and Safety of Ketamine for Suicidal Patients in the Emergency Department
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Acutely suicidal with positive response to suicidal ideation questions on C-SSRS
- Require inpatient stabilization for suicidal ideation or actions
- Accepted for psychiatric stabilization at University of Kansas Medical Center's Strawberry Hill campus
- Glasgow Coma Score of 15
- Age between 18 and 65 years
You will not qualify if you...
- Current or past history of psychosis
- Current or recent symptoms of mania/hypomania (Young Mania Rating Scale score of 12 or greater in past 4 weeks)
- History of ketamine use disorder
- History of liver transplant
- Pregnancy or breastfeeding
- Imprisonment or inability to consent
- Positive urine drug screen or serum alcohol level
- Hypertension (SBP > 160 or DBP > 100 before ketamine)
- Hypotension (SBP < 90)
- Acute medical condition requiring admission to medical service
- Allergy, intolerance, or previous adverse reaction to ketamine
- Patient has 8 or more lifetime ketamine exposures
- Treating physician deems patient not a good candidate for ketamine treatment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
University of Kansas Strawberry Hill Campus
Kansas City, Kansas, United States, 66101
Not Yet Recruiting
2
University of Kansas Medical Center Emergency Department
Kansas City, Kansas, United States, 66160
Actively Recruiting
Research Team
L
Lindsay Maguire, MD
CONTACT
L
Lucas Lemar
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here