Actively Recruiting
Feasibility, Safety, and Preliminary Efficacy of Median Nerve Stimulation for Cognitive Dysfunction in Patients With Acute Traumatic Brain Injury
Led by Beijing Tiantan Hospital · Updated on 2026-02-17
30
Participants Needed
1
Research Sites
99 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Currently, the treatment of cognitive dysfunction after acute TBI remains a challenge, and novel therapeutic methods are urgently needed. Median nerve stimulation (MNS) is a non-invasive neuromodulation technique and recently has shown positive effects in awaking coma of acute brain injury. It has been shown to improve cognition in healthy volunteers and may be a potential therapeutic approach for cognitive dysfunction in patients with acute TBI. Therefore, the main purpose of the study is to evaluate the feasibility, safety, and preliminary efficacy of MNS for cognitive dysfunction in patients with acute TBI.
CONDITIONS
Official Title
Feasibility, Safety, and Preliminary Efficacy of Median Nerve Stimulation for Cognitive Dysfunction in Patients With Acute Traumatic Brain Injury
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 18-64 years
- Admitted within 3 days after injury with Glasgow Coma Scale score of 9-12 and imaging abnormalities
- Cognitive dysfunction within 1 week after injury with Mini-Mental State Examination score 26 or below
- Pre-injury Clinical Dementia Rating score of 0 as reported by family
- At least 6 years of education and able to understand instructions and cooperate with assessments, MRI, and MEG examinations
You will not qualify if you...
- Need for emergency neurosurgical intervention such as surgery or device placement
- Unstable vital signs or unstable cardiac, pulmonary, liver, kidney, or blood system disorders
- Pre-existing central nervous system conditions causing cognitive decline, including previous traumatic brain injury, brain infection, brain tumor, epilepsy, stroke, neurodegenerative diseases, carbon monoxide poisoning, or alcohol abuse
- Severe visual or hearing impairment, psychiatric or behavioral disorders, MRI contraindications, or intolerance to MEG
- Short life expectancy due to critical illness
- Right forearm skin lesions, right median nerve injury, brachial plexus injury, cervical spinal cord injury, or intolerance to median nerve stimulation
- Pregnant or breastfeeding women
- Participation in other ongoing clinical trials
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Beijing Tiantan Hospital, Capital Medical University
Beijing, Beijing Municipality, China, 100070
Actively Recruiting
Research Team
L
Liang Wu, MD
CONTACT
Y
Yu Deng, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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