Actively Recruiting
Feasibility of Semaglutide in Advanced Lung Disease
Led by University of Pennsylvania · Updated on 2026-04-21
8
Participants Needed
1
Research Sites
204 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn whether semaglutide, an FDA-approved treatment for diabetes and obesity, is feasible and tolerable in patients with advanced lung disease. The main question\[s\] it aims to answer are: 1. Are patients with advanced lung disease able to tolerate semaglutide therapy? 2. Are we able to titrate semaglutide therapy to a target weight? Participants will be asked to perform pulmonary function, physical function and body composition testing, as well as a blood draw before and after 12-weeks of semaglutide therapy. While on therapy, subjects will be surveyed regarding any adverse events or side effects.
CONDITIONS
Official Title
Feasibility of Semaglutide in Advanced Lung Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of interstitial lung disease, sarcoidosis, chronic obstructive pulmonary disease, or pulmonary hypertension
- Age over 18 years
- Body mass index over 30 kg/m2
- Requires supplemental oxygen during exertion
- Stable treatment regimen for at least 90 days
- Currently using disease-modifying therapy
You will not qualify if you...
- Diagnosis of diabetes
- Pregnant or breastfeeding
- Recent weight loss
- Recent or chronic gastrointestinal complaints
- History of gastroparesis
- History of scleroderma
- Hospitalized at time of evaluation
- Use of weight loss medication in past 90 days
- Personal or family history of medullary thyroid cancer or multiple endocrine neoplasia type 2
- Uncontrolled thyroid disease
- History of acute or chronic pancreatitis
- Prior suicide attempt
- Suicidal thoughts in past 90 days
- Presence of pacemaker or defibrillator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Pennsylvania Perelman School of Medicine
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
Research Team
M
Michaela R Anderson, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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