Actively Recruiting
Feasibility Study of CBCT for IGRT in Cancer Patients
Led by Varian, a Siemens Healthineers Company · Updated on 2026-03-13
50
Participants Needed
4
Research Sites
79 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Cone beam computed tomography (CBCT) is an imaging technology that is incorporated into many modern radiation therapy systems. The quality of conventional CBCT is good enough to align patients for their daily radiation therapy but CBCT images have poor contrast and are susceptible to imaging artefacts that limit their usability for other tasks in the radiation therapy workflow. Varian Medical Systems, the sponsor of this study, has developed new CBCT imaging technology called HyperSight that so far has demonstrated increased image quality compared with conventional CBCT images. This new HyperSight CBCT imager has previously been built into Varian Halcyon and Ethos treatment machines, where the imager is enclosed in a ring that rotates around the patient. Now, HyperSight has been built into a Varian treatment machine, called TrueBeam, where the imager is mounted on a C-shaped arm that rotates around you to acquire an image. This study is being done to evaluate the image quality of HyperSight CBCT compared to conventional CBCT images, and to determine whether HyperSight CBCT can improve the process of delivering radiation treatments. The goal of this study is to collect images from this new HyperSight-TrueBeam CBCT imager from a variety of patients and locations in the body. The images will be analyzed to determine whether their quality is high enough to use for tasks other than positioning patients for treatment. For example, the study will determine whether the HyperSight images could be used to calculate a radiation plan.
CONDITIONS
Official Title
Feasibility Study of CBCT for IGRT in Cancer Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient age 18 years or older
- Receiving radiation therapy for head and neck, thorax, liver, breast, genitourinary, or gastrointestinal cancers
- CBCT imaging is part of the standard radiation therapy treatment plan
You will not qualify if you...
- ECOG Performance Status 3 or higher
- Wheelchair bound
- Life expectancy less than 3 months
- Unable or unwilling to provide informed consent
- Pregnant or planning pregnancy during treatment
- Part of a vulnerable population as defined by ISO 14155:2020, including prisoners
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 4 locations
1
James Outpatient Center
Columbus, Ohio, United States, 43210
Actively Recruiting
2
Ohio State University, Brain and Spine Hospital
Columbus, Ohio, United States, 43210
Actively Recruiting
3
The Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
Columbus, Ohio, United States, 43210
Actively Recruiting
4
Stefanie Spielman Comprehensive Breast Center
Columbus, Ohio, United States, 43212
Actively Recruiting
Research Team
S
Sean Davidson
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
OTHER
Number of Arms
1
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