Actively Recruiting
Feasibility Study of Diaphragm Synchronized Pacing (DSP) Via the Left Inferior Phrenic Vein (LIPV) Approach
Led by RenJi Hospital · Updated on 2026-02-06
10
Participants Needed
1
Research Sites
17 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Cardiac resynchronization therapy（CRT） benefits a portion of patients, while more patients are not yet indicated to a therapy that mechanically helps the heart systole and/or diastole. Synchronized diaphragmatic pacing may be feasible to induce diaphragm local contraction and recoil that enhance pump function of the heart, thus improve cardiac function and QoL. This acute, interventional study is conducted in a single site, Renji Hospital, to evaluate the feasibility of diaphragm pacing and assess the beneficial effect of pacing-regulated diaphragm movement to the heart, with 10 cases of sample size and one-week follow-up after discharge.
CONDITIONS
Official Title
Feasibility Study of Diaphragm Synchronized Pacing (DSP) Via the Left Inferior Phrenic Vein (LIPV) Approach
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged �3e=18 years
- Patients indicated for CRT or CRT-D, planned for left ventricular lead implantation
- Patients willing to participate and provide signed informed consent
You will not qualify if you...
- CRT or CRT-D replacement
- History of ischemic heart disease with coronary artery bypass graft (CABG)
- History of diaphragm dysfunction
- History of phrenic nerve injury
- History of inferior vena cava (IVC) filter
- History of abdominal surgery
- Splenomegaly
- Pulmonary disease
- Moderate or severe liver cirrhosis
- Severe hepatic or renal dysfunction
- Currently pregnant or planning pregnancy during the study period
- Participation in another study that may confound this study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Renji Hospital
Shanghai, Shanghai Municipality, China, 200127
Actively Recruiting
Research Team
T
Tianbao Dr. Yao, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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