Actively Recruiting
Feasibility Study to Investigate Rectal Mucus in Aero-Digestive Tract Cancer.
Led by Origin Sciences · Updated on 2026-03-16
450
Participants Needed
1
Research Sites
313 weeks
Total Duration
On this page
Sponsors
O
Origin Sciences
Lead Sponsor
R
Royal Devon and Exeter NHS Foundation Trust
Collaborating Sponsor
AI-Summary
What this Trial Is About
The aim of the study is to assess the feasibility of genomic and epigenetic analysis of rectal mucus to detect non-colorectal cancers of the aero- digestive tract using samples collected by the OriCol™ Sampling Device. The primary objective of the study is to assess whether significant changes in DNA mutation and methylation associated with Non-colorectal cancers of the Aero-digestive Tract (NCRCADT) can be detected in rectal mucus as shed cells and cell-free DNA (cfDNA) pass through the gut and theoretically can be collected from rectal mucus. Secondary objectives will assess the participant acceptability of the OriCol™ Sampling Device for Pancreatic Ductal Adenocarcinoma, Non-Small Cell Cancer of the Lung, Colorectal Cancer and Urological Cancer controls as well as contributing to a genomic library collating information about rectal mucus.
CONDITIONS
Official Title
Feasibility Study to Investigate Rectal Mucus in Aero-Digestive Tract Cancer.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 18 years or over
- Able to give voluntary, written informed consent to participate in the study
You will not qualify if you...
- Symptoms making proctoscopic examination inappropriate, including acute anal fissure, symptomatic thrombosed haemorrhoids, or obstructing anorectal lesions
- Previous history of cancer
- Previous treatment with radiotherapy, chemotherapy, or immunotherapy for any malignancy
AI-Screening
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Trial Site Locations
Total: 1 location
1
Royal Devon & Exeter NHS Foundation Trust
Exeter, United Kingdom, EX2 4UG
Actively Recruiting
Research Team
I
Ian Daniels, FRCS
CONTACT
H
Hugo Lywood
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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