Actively Recruiting
Feasibility Study of Ocular Surface Squamous Neoplasia Surgical Excision in People Living With HIV in Sub-Saharan Africa
Led by AIDS Malignancy Consortium · Updated on 2026-03-23
84
Participants Needed
1
Research Sites
236 weeks
Total Duration
On this page
Sponsors
A
AIDS Malignancy Consortium
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Participants will undergo surgical excision of OSSN at baseline and will be followed at 1 week, 6 weeks, 6 months, and 12 months for post-surgical follow up. This study is being conduced to assess the feasibility of conducting multi-center prospective studies on surgical excision of suspected OSSN lesions in SSA in people living with HIV/AIDS (PLWHA). Participants include those with HIV infection and with suspected non-invasive OSSN lesions that the AMC-certified ophthalmologist determines can be resected with 3 mm clinical margins, sparing involvement of the superior and inferior fornices and 6 clock hours of the corneal scleral limbus.
CONDITIONS
Official Title
Feasibility Study of Ocular Surface Squamous Neoplasia Surgical Excision in People Living With HIV in Sub-Saharan Africa
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Suspected unilateral, non-invasive OSSN lesion that can be surgically removed with 3 mm clinical margins, sparing the superior and inferior fornices and up to 6 clock hours of the corneal scleral limbus
- Confirmed HIV-1 infection documented by ART prescription, HIV RNA assay, or licensed antibody/antigen tests with confirmatory testing
- Performance status of 2 or less on the WHO scale
You will not qualify if you...
- Receiving any other investigational agents within 30 days before surgery, except investigational ART regimens
- History of ocular surface lesions including OSSN, other ocular tumors, pterygia, or limbal vernal keratoconjunctivitis
- Uncontrolled illness or infection within 4 weeks before enrollment, or psychiatric/social issues limiting study compliance
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Uganda Cancer Institute
Kampala, Uganda
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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