Actively Recruiting
Feasibility Study of Personalized Ultra-fractionated Stereotactic Ablative Radiotherapy (PULSAR) for Cancers of the Central Lung
Led by University of Texas Southwestern Medical Center · Updated on 2025-11-10
30
Participants Needed
1
Research Sites
167 weeks
Total Duration
On this page
Sponsors
U
University of Texas Southwestern Medical Center
Lead Sponsor
E
Elekta Limited
Collaborating Sponsor
AI-Summary
What this Trial Is About
The objective of this study is to enhance the safety profile of SAbR in ultra-central tumors of the lung (primary or metastatic) without compromising its effectiveness.
CONDITIONS
Official Title
Feasibility Study of Personalized Ultra-fractionated Stereotactic Ablative Radiotherapy (PULSAR) for Cancers of the Central Lung
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 years of age or older
- Histologically confirmed diagnosis of cancer with lung tumor related to biopsy site
- Tumor size between 1.5 and 5 cm in maximum diameter
- Tumor located entirely within 2 cm central lung zone or within 1 cm of mediastinum, esophagus, or proximal bronchial tree
- Zubrod/ECOG Performance Status of 0 to 2 within 30 days before registration
- Ability to tolerate MRI
- Men and women of child-bearing potential must agree to use effective contraception during the study and for 90 days after treatment completion
You will not qualify if you...
- Prior radiotherapy overlapping the study cancer region
- Plans to receive other local lung therapy during the study except if disease progresses
- Women who are pregnant, breastfeeding, or not using effective birth control if of reproductive potential
- Prior anti-VEGF therapy within 1 year before study entry
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Texas Southwestern Medical Center
Dallas, Texas, United States, 75390
Actively Recruiting
Research Team
S
SARAH NEUFELD, MS, MBA
CONTACT
K
KENNETH WESTOVER, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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