Actively Recruiting
A Feasibility Study Using CLINIMACS® for Alpha/Beta T-Cell Depletion in Stem Cell Transplant
Led by Christopher Dvorak · Updated on 2026-04-13
90
Participants Needed
1
Research Sites
784 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Patients in need of an allogeneic hematopoietic cell transplant (HCT) are at risk of developing graft-versus-host-disease (GVHD). In certain clinical situations, the optimal approach to minimize the risk of GVHD is to perform ex vivo alpha-beta T-cell depletion of the donor cells. However, the CliniMACS® Device is FDA-approved only for a narrow indication. All other uses of ex vivo processed cells must be done under a feasibility study protocol.
CONDITIONS
Official Title
A Feasibility Study Using CLINIMACS® for Alpha/Beta T-Cell Depletion in Stem Cell Transplant
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female 0-30 years of age at time of transplant admission
- Documentation of a disease requiring hematopoietic cell transplant
- A healthy and willing donor (mismatched related or unrelated) able to donate bone marrow or peripheral blood stem cells; matched related donors allowed for Fanconi Anemia
- Written informed consent and ability to comply with study requirements
You will not qualify if you...
- Pregnant, breastfeeding, or unwilling to use birth control during the study
- Any condition or abnormality that may compromise patient safety or data quality
- Presence of a healthy and willing HLA-identical related donor (except for Fanconi Anemia patients)
- Anticipated life expectancy less than 1 month
- Known hypersensitivity to murine (mouse) proteins or iron dextran
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of California, San Francisco
San Francisco, California, United States, 94143
Actively Recruiting
Research Team
C
Christopher C. Dvorak, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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