Actively Recruiting
Feasibility Study of Uterine Transplantation From Living Donors in Terms of Efficacy and Safety in Patients With Mayer-Rokitansky-Küster-Hauser Syndrome (MRKH)
Led by Hopital Foch · Updated on 2025-03-07
20
Participants Needed
1
Research Sites
887 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
In France, one in 4500 women is affected by the MayerRokitantskyKüsterHauser (MRKH) syndrome which is characterized by the absence of uterus at birth. Currently, the only solutions for these patients are: * Gestational surrogacy, prohibited in France * Adoption * Resignation Uterine transplantation could become a good alternative. This study is conducted in 10 patients with MRKH type I syndrome, who will be transplanted from a living donor uterus
CONDITIONS
Official Title
Feasibility Study of Uterine Transplantation From Living Donors in Terms of Efficacy and Safety in Patients With Mayer-Rokitansky-Küster-Hauser Syndrome (MRKH)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female patients aged between 18 and 38 years
- Diagnosis of Mayer-Rokitansky-Küster-Hauser Type I Uterine Vaginal Agenesis without renal, cardiac, or bone malformations
- In a stable relationship with a pregnancy plan and favorable psychological evaluation
- No history of cancer or blood transfusion
- Living donor is a related woman without neurological, nephro-urological, infectious, psychiatric, or psychological conditions
- Living donor has no history of uterine surgery or major abdomino-pelvic pathology
You will not qualify if you...
- Recipient with severe sperm issues in the husband (extreme oligo-astheno-spermia or azoospermia)
- Recipient with history of abdominopelvic surgery except uncomplicated appendectomy or vaginal residue preventing anastomosis
- Living donor with known thromboembolic risk factors
- Living donor incompatible with recipient by blood group, rhesus factor, or HLA
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Hopital Foch
Suresnes, France, 92150
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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