Study of Attentional-Control Training Using EndeavorRx in Children Aged 8 to 16 Who Survived Pediatric Leukemia or Brain Tumors

What this Trial Is About

Researchers are evaluating the feasibility, acceptability, and preliminary effectiveness of EndeavorRx, an FDA-approved electronic attentional-control training program, in children aged 8 to 16 who have survived acute lymphoblastic leukemia ALL or brain tumors and are at least one year past their cancer treatment. These survivors often face long-term cognitive challenges affecting attention, working memory, and executive functioning, which impact daily life, school, and social activities. The study is a multicenter pilot randomized controlled trial aiming to explore this new approach to help improve cognitive difficulties in this group. Participants will be randomly assigned to one of two groups the EndeavorRx intervention group or an active control group. Those in the EndeavorRx group will complete 25-30 minute digital attentional control training sessions at home, five days per week, for four weeks, totaling 120 training missions. The control group will engage in a digital word game designed to match the interventions duration and engagement but focuses on cognitive skills not related to attention. Both programs are delivered through digital devices, with training starting within six weeks of baseline testing. During the study, participants will undergo neurocognitive testing before and after the intervention period, while parents will fill out questionnaires about their childs functioning. Researchers will monitor adherence to the training, satisfaction, and ease of use. They will measure changes in attention and executive functioning through tests like the Conners Continuous Performance Test and the Behavior Rating Inventory of Executive Functioning. Follow-up assessments will occur up to four months post-training to evaluate sustained effects. The study is designed to last several months, including screening, training, and follow-up evaluations.

Feasibility/Acceptability of Attentional-Control Training in Survivors