Actively Recruiting
Febrile Disease Landscape in Cambodia Via Metagenomic Pathogen Sequencing
Led by National Institute of Allergy and Infectious Diseases (NIAID) · Updated on 2026-04-08
6500
Participants Needed
6
Research Sites
362 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Background: Vector-borne diseases are caused by the bite of an infected mosquito, fly, flea, tick, or other blood-feeder. These diseases cause almost 1 million deaths per year. And they are on the rise, particularly in Southeast Asia in particular. Researchers think that these diseases make up about 10 percent of fevers in Cambodia. But many of these illnesses are never diagnosed. Studying these diseases can help find new ways to identify and treat them. Objective: To find pathogens in people who have a fever using metagenomic pathogen sequencing platforms. Eligibility: People aged 2 months to 65 years with a fever of at least 38 degrees Celsius or those diagnosed with infection by a pathogen of concern who visit the referral hospital in Cambodia. Close contacts of people diagnosed with infection by a pathogen of concern may also be enrolled. Design: Participants will be screened with their medical history. Children will be weighed to make sure they are big enough to give blood samples. Participants will share data about their sex, age, and where they live. They will answer more questions about their heath history. They will answer questions about and any places to which they have recently traveled. They will take a questionnaire. They will have a blood test. If they have respiratory symptoms, they will have a nasal swab. Participants may be contacted within 1-2 weeks (early) and/or within 3 months (late) from their enrollment date to provide an optional follow-up blood samples and nasal swabs.
CONDITIONS
Official Title
Febrile Disease Landscape in Cambodia Via Metagenomic Pathogen Sequencing
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed and dated informed consent form.
- Willingness to comply with all study procedures.
- Male or female, aged 2 months to 65 years.
- Meets one of the following: febrile patient with fever ≥38°C within past 24 hours; red flag patient with confirmed infection by a concerning pathogen; afebrile close contact living or working daily with a red flag patient.
- Willing to allow biological samples and de-identified genetic data to be stored for future research.
You will not qualify if you...
- Any chronic or current medical condition that interferes with study participation (e.g., difficulty drawing blood).
- Febrile individuals who had surgery within the past month.
- Patients who enrolled and exited the study within 30 days of initial blood draw, or afebrile close contacts who exited within 14 days.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 6 locations
1
Kampong Speu Referral Hospital
Chbar Mon, Cambodia
Actively Recruiting
2
Kantha Bopha Hospital
Phnom Penh, Cambodia
Actively Recruiting
3
Khmer-Soviet Friendship Hospital
Phnom Penh, Cambodia
Actively Recruiting
4
National Pediatric Hospital
Phnom Penh, Cambodia
Actively Recruiting
5
Preah Kossomak Hospital
Phnom Penh, Cambodia
Actively Recruiting
6
Takeo District Referral Hospital
Takeo, Cambodia
Actively Recruiting
Research Team
C
Christina C Yek, M.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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