Actively Recruiting
Fecal Microbiota Transplantation in aGvHD After ASCT
Led by Medical University of Graz · Updated on 2025-12-02
15
Participants Needed
1
Research Sites
513 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Acute graft-versus-host-disease (aGvHD) is a typical complication after allogeneic hematopoetic stem cell transplantation (ASCT). About 30-60% of patients after ASCT are affected by aGvHD, which constitutes a relevant burden of morbidity and mortality in these patients. Fecal microbiota transplantation (FMT) is a therapeutic concept to treat intestinal dysbiosis of various origin by infusion of the stool microbiota of a healthy donor into the gastrointestinal tract (GI) of a patient. FMT can be performed endoscopically by colonoscopic deployment of the donor microbiota into the patient´s caecum and terminal ileum. Patients with gastrointestinal aGvHD (GI-aGvHD) are known to comprise a significant dysbiotic colonic microbiota that can be attenuated by FMT.
CONDITIONS
Official Title
Fecal Microbiota Transplantation in aGvHD After ASCT
Who Can Participate
Eligibility Criteria
You may qualify if you...
- First episode of histologically confirmed, steroid-refractory gastrointestinal acute graft-versus-host disease (GI-aGvHD)
- Reduced bacterial diversity in the patient's stool microbiota confirmed by 16s-rDNA measurement
- Eligible for repeated colonoscopic procedures
- Provided informed consent
You will not qualify if you...
- Complications during a previous colonoscopy
- Recurrent episode of gastrointestinal acute graft-versus-host disease (GI-aGvHD)
- Lack of cardiopulmonary fitness for repeated colonoscopic procedures
- Presence of septic infection
- Acute extraintestinal organ failure (excluding bone marrow)
- Mechanical ileus
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz
Graz, Styria, Austria, 8036
Actively Recruiting
Research Team
W
Walter DDr. Spindelboeck
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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