Study of Fecal Microbiota Transplantation Safety and Effects in Adults With Acute-on-chronic Liver Failure

What this Trial Is About

Researchers are investigating the safety, side effects, and potential benefits of fecal microbiota transplantation in patients with liver failure. The study also aims to understand how this treatment affects the gut bacteria and the connection between the gut and liver immune system. The research intends to optimize fecal microbiota transplantation techniques to improve treatment outcomes for liver failure patients. Participants receive fecal microbiota transplantation every 5 days, with a total of four treatments given. This intervention involves transplanting healthy fecal bacteria to the patients intestines to study its effects on liver failure. The treatment schedule is fixed, with follow-up visits planned to monitor changes over time. During the study, participants will have blood and fecal samples collected before the first transplantation and at several points after treatment at 5, 10, 15, and 20 days, as well as 4 and 8 weeks later. These samples will help track liver and coagulation function, gut microbiota changes, immune system markers, and clinical symptoms. The study also observes safety and any adverse reactions throughout the follow-up period, providing a comprehensive view of the treatments effects over approximately two months.

Fecal Microbiota Transplantation for Liver Failure