Actively Recruiting
Fecal Microbiota Transplantation for the Prevention of Infectious Complications After Liver Transplantation
Led by IRCCS Azienda Ospedaliero-Universitaria di Bologna · Updated on 2025-01-20
144
Participants Needed
1
Research Sites
160 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The increasing emergence and spread of MDRB represents a major public health problem, with higher mortality in patients experiencing infections. Cirrhotic patients listed for OLT and after OLT are at high risk of MDRB colonization or infection due to the large use of broad-spectrum antibiotics in the post-transplant setting. Therefore, effective decolonization strategies in this particular setting are urgently needed. The investigators hypothesize that heterologous FMT can reduce infections rates in the pre-and post- OLT setting by MDRB decolonization and restoration of a more physiological microbiome.
CONDITIONS
Official Title
Fecal Microbiota Transplantation for the Prevention of Infectious Complications After Liver Transplantation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult (age6518 years) patients listed for OLT for various etiologies.
- Patient's consent to participate in the study
You will not qualify if you...
- Previous total colectomy
- Pregnancy or breastfeeding
- Patients on oral or intravenous antimicrobial agents
- HIV positive and not well controlled on antiretroviral therapy, or CD4+ <200/ mm3
- Active SARS-CoV-2 infection
- Neutropenia <0.5X10^9/L
- Toxic megacolon
- Contraindications to colonoscopy
- Any conditions for which, according to the physician, FMT endangers the patient's health
- History of hypersensitivity to macrogol contained in bowel preparations.
AI-Screening
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Trial Site Locations
Total: 1 location
1
IRCCS Azienda Ospedaliero-Universitaria di Bologna
Bologna, Italy, 40138
Actively Recruiting
Research Team
G
Giovanni Barbara, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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