Actively Recruiting
FECD-TRACE: Fuchs' Endothelial Corneal Dystrophy TRAjectory and Correlation With Genotype in the United Kingdom
Led by University College, London · Updated on 2025-03-18
500
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
FECD-TRACE is an integral component of a large research program dedicated to Fuchs Endothelial Corneal Dystrophy (FECD) in the United Kingdom. This longitudinal, observational study aims to comprehensively characterize a cohort of younger research participants who have a genetic predisposition to developing FECD. By utilizing advanced anterior segment imaging techniques, the study will monitor these individuals over a span of several years, capturing phenotypic changes that reflect the progression of the disease. Concurrently, genetic biomarkers will be examined to establish correlations with the observed phenotypic changes. The primary objective of FECD-TRACE is to enhance our understanding of the intricate genetic mechanisms underlying FECD and establish connections between these genetic findings and clinical outcomes. Ultimately, this research strives to facilitate the development of personalized care approaches for individuals affected by FECD.
CONDITIONS
Official Title
FECD-TRACE: Fuchs' Endothelial Corneal Dystrophy TRAjectory and Correlation With Genotype in the United Kingdom
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Willing and able to provide informed consent for participation in the study
- Willing to attend scheduled study visits and undergo a clinical examination
- Willing to donate blood/saliva samples
- Fulfil the abovementioned cohort criteria
You will not qualify if you...
- Presence of a secondary cause for corneal endothelial dysfunction or oedema
- Presence of clinically evident corneal oedema
- History of concurrent corneal diseases
- History of corneal surgeries, including corneal transplantation
- Cognitive impairment or inability to provide informed consent for participation in the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University College London
London, United Kingdom, EC1V 9EL
Actively Recruiting
Research Team
S
Siyin Liu, MBChB
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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