Actively Recruiting
Feeding Mom Feeding Infant's Microbiota: Nutritional Strategies for Improving Breast Milk Composition and Infant Health
Led by The Hong Kong Polytechnic University · Updated on 2024-08-06
200
Participants Needed
1
Research Sites
175 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The first 1000 days, i.e., the earliest stage of life, is a unique period of opportunity to establish the foundations of human growth and health through the lifespan. In the recent decades, multiple studies have explored nutritional strategies for improving infant health through improving the nutritive and bioactive compositions in breast milk. For example, dietary fiber intake has been increasingly reported to benefit the health of the mother-infant dyad. However, the complex interplays among maternal diet, breast milk composition, infant gut microbiota and infant development are yet to be elucidated in a prospective cohort. In addition, the investigators' previous work has revealed unsatisfactory dietary patterns in Hong Kong lactating women, with clear inadequacy in fruit and vegetable intake. In this prospective cohort study, the investigators aim to recruit 100 healthy Chinese mother-child pairs. Data on maternal and infant dietary intake, breast milk composition, gut microbiota profile will be collected and the investigators will examine their associations with the health outcomes in infants. In addition, the influence of dietary factors and genetic predisposition on breast milk components and its associated benefits in the child will be interrogated. With the employment of multidisciplinary research approaches, cutting-edge biotechnologies and the omics platforms, this project will provide novel insights into the dietary factors and breastfeeding practices that are beneficial to the infant developmental trajectory, and the potential roles of breast milk composition in shaping infant's gut microbiota and the associated health impact in the long term. More importantly, the investigators hope to generate more solid scientific data to inform the public of the importance of maternal diet and the practical nutritional strategies to improve breast milk composition for the sake of the child.
CONDITIONS
Official Title
Feeding Mom Feeding Infant's Microbiota: Nutritional Strategies for Improving Breast Milk Composition and Infant Health
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Hong Kong residents aged 18-40 years old
- Vaginal delivery between 37 and 42 weeks of gestation
- Carrying a singleton pregnancy
- Breastfeeding for more than 80% of feeding occasions upon recruitment
- Intend to continue breastfeeding at least until the infant reaches 3 months old
- Infants delivered between 37 and 42 weeks
- Infants born by vaginal delivery
- Singleton infant with no known abnormality
You will not qualify if you...
- Complicated pregnancy such as preeclampsia and gestational diabetes
- Special dietary restrictions such as gluten-free diets, vegan diets, or any restrictions due to food allergies
- Renal, liver, or thyroid dysfunction, cognitive impairment, or any major medical or psychological illness judged ineligible by investigators
- No intention to continue breastfeeding beyond 3 months
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
The Hong Kong Polytechnic University
Hong Kong, China
Actively Recruiting
Research Team
W
Wing Wa Ho, bachelor
CONTACT
K
Ka Hei Kenneth Lo, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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