Actively Recruiting
Femoral BMD Change Following Cemented or Cementless Total Knee Arthroplasty
Led by University of Wisconsin, Madison · Updated on 2026-02-19
100
Participants Needed
1
Research Sites
169 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to examine femur bone mineral density (BMD) change before and after surgery in patients receiving cemented or cementless total knee arthroplasty (TKA). performed with manual or robotic methods. 100 participants will be enrolled and can expect to be on study for up to 26 months.
CONDITIONS
Official Title
Femoral BMD Change Following Cemented or Cementless Total Knee Arthroplasty
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients age 55 years or older undergoing total knee arthroplasty with no prior joint replacement on the surgical side
- Normal bone mineral density or osteopenia without meeting Bone Health and Osteoporosis Foundation treatment recommendations based on fracture risk assessment
- Fracture Risk Assessment Tool (FRAX) showing less than 20% 10-year major osteoporotic fracture risk and less than 3% hip fracture risk
You will not qualify if you...
- Known clinical osteoporosis defined by hip or spine T-score ≤ -2.5
- History of low trauma fracture after age 50
- FRAX fracture risk ≥ 20% for major osteoporotic fracture or ≥ 3% for hip fracture
- Prior or current use of osteoporosis medications
- Current use of systemic glucocorticoids or bone-active medications
- Rheumatoid arthritis
- Laboratory abnormalities affecting bone mineral density including calcium, creatinine, albumin, and parathyroid hormone
- 25(OH)D levels less than 20 ng/mL
- Other reasons deemed unsuitable for study participation by investigators
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
UW School of Medicine and Public Health
Madison, Wisconsin, United States, 53792
Actively Recruiting
Research Team
O
Osteoporosis Clinical Research Program
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
4
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