Actively Recruiting
FeNO Observation Study in ICU Patients With ARS
Led by Shanghai Zhongshan Hospital · Updated on 2024-11-08
1000
Participants Needed
1
Research Sites
78 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
1. Main Objective: To compare the concentration of exhaled nitric oxide in patients with different severity of respiratory failure in ICU. 2. Secondary Purpose: 1. To observe the change of nitric oxide concentration in exhaled breath of patients with mechanical ventilation over time; 2. The relationship and differences between pulmonary ventilation blood flow levels in patients with different exhaled NO concentrations; 3. Reactivity of patients with different exhaled NO concentrations to inhaled nitric oxide therapy and the relationship between them.
CONDITIONS
Official Title
FeNO Observation Study in ICU Patients With ARS
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients (≥18 years of age) with mechanical ventilation or advanced respiratory support in the ICU, regardless of gender
- Expected mechanical ventilation time of tracheal intubation is more than 24 hours
- Initial ventilator settings: oxygen fraction (FIO2) = 50%, respiratory rate = 15/min, positive end-expiratory pressure (PEEP) = 5 cmH2O, tidal volume = 6-8 ml/kg ideal body weight (IBW), inspiration-exhalation ratio = 1:2
- Agree to participate and sign informed consent
You will not qualify if you...
- Use of any nitric oxide containing drugs, anti-inflammatory drugs, or drugs affecting airway diameter within 6 hours before the first FeNO measurement
- Participation in other clinical research projects
- Patients deemed unsuitable by the investigators
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Shanghai Zhongshan hospital
Shanghai, Shanghai Municipality, China, 200030
Actively Recruiting
Research Team
H
Huan Wang, Master
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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