Actively Recruiting
Fenofibrate in Patients With Cervical Intraepithelial Neoplasia and Invasive Cervical Carcinoma
Led by Lindsay Ferguson, MD · Updated on 2025-10-02
24
Participants Needed
1
Research Sites
105 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Normally, p53 helps prevent tumors from forming in the body. Early studies have shown that Fenofibrate, a cholesterol-lowering drug, can restore normal function to p53 and can change the metabolism of HPV-positive tumors in a way that stops the growth of tumors. The purpose of this study is to understand how Fenofibrate can be used to treat HPV-positive cervical cancers and cervical dysplasia. Researchers will examine collected tissue samples and investigate various genes and proteins to see whether Fenofibrate has an effect on HPV-positive cervical cancers and cervical dysplasia.
CONDITIONS
Official Title
Fenofibrate in Patients With Cervical Intraepithelial Neoplasia and Invasive Cervical Carcinoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Have confirmed high-grade cervical dysplasia or cervical cancer (including squamous cell, adenocarcinoma, or adenosquamous cell carcinoma)
- Eligible for surgical treatment with LEEP, cold knife conization, hysterectomy, or chemoradiation
- 18 years of age or older
- Normal liver function tests (AST, ALT, bilirubin within normal limits)
- Able to speak English
- Able and willing to sign informed consent
You will not qualify if you...
- Have active liver disease or unexplained liver function abnormalities
- Have severe kidney impairment or are on dialysis
- Have preexisting gallbladder disease including active gallstones
- Are allergic to fenofibrate or fenofibric acid
- Are pregnant or breastfeeding
- Participants of childbearing potential are screened for pregnancy before procedures and treatment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University Hospitals Cleveland Medical Center, Case Comprehensive Cancer Center
Cleveland, Ohio, United States, 44106
Actively Recruiting
Research Team
L
Lindsay A Ferguson, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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