Actively Recruiting
Fertility and Ovarian Reserve in Female Childhood Cancer Survivors
Led by Centre Hospitalier Universitaire de Liege · Updated on 2024-11-01
340
Participants Needed
3
Research Sites
220 weeks
Total Duration
On this page
Sponsors
C
Centre Hospitalier Universitaire de Liege
Lead Sponsor
L
La Fondation contre le cancer, Belgique
Collaborating Sponsor
AI-Summary
What this Trial Is About
Ovarian function impairment affects the quality of life of the survivors of paediatric cancer by impacting fertility, bone quality and mental and cognitive health. The objective of this project is to evaluate the impact of low-intermediate dose alkylating agents associated or not with ovarian cryopreservation technique on ovarian function in female survivors of paediatric cancer. We propose to identify new epigenetic markers in order to predict the risk of premature ovarian insufficiency. The project will be led by a national multi-disciplinary team (paediatric oncologists, gynaecologists, endocrinologists). Paediatric cancer clinical data (therapy, fertility preservation, ...) will be extracted from the Paediatrics Late Effects database and additional data will be collected during PRINCESS fertility evaluation. Through translational and multi-disciplinary approaches, results should improve quality of life and fertility preservation in female survivors of paediatric cancer by developing new personalised screening tools for premature ovarian insufficiency.
CONDITIONS
Official Title
Fertility and Ovarian Reserve in Female Childhood Cancer Survivors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female patients diagnosed with cancer between January 1, 2004 and December 31, 2018
- Diagnosed before 17 years of age
- Treated at CHU Li�e8ge site Citadelle, CHC Cliniques Universitaires Saint-Luc, or HUDERF
- Currently alive
- At least 18 years old at time of recruitment
You will not qualify if you...
- Cancer diagnosis for controls
AI-Screening
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Trial Site Locations
Total: 3 locations
1
Hopital de la Citadelle
Liège, Wallonia, Belgium, 4000
Actively Recruiting
2
Cliniques Universitaires Saint-Luc
Brussels, Belgium, 1020
Not Yet Recruiting
3
HUDERF
Brussels, Belgium, 1020
Not Yet Recruiting
Research Team
B
Bianca David, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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