Actively Recruiting
Fertility Preservation in Children With Solid Tumors: Detection of Residual Disease by a Sensitive Method
Led by University Hospital, Clermont-Ferrand · Updated on 2025-09-03
89
Participants Needed
1
Research Sites
151 weeks
Total Duration
On this page
Sponsors
U
University Hospital, Clermont-Ferrand
Lead Sponsor
U
University Hospital, Rouen
Collaborating Sponsor
AI-Summary
What this Trial Is About
In prepubertal patients, cryopreservation of ovarian or testicular tissue is currently the only available method for fertility preservation prior to gonadotoxic cancer treatments. However, this approach carries the risk of reintroducing malignant cells upon autotransplantation, particularly in cases of metastatic cancers such as neuroblastoma and Ewing sarcoma. Therefore, it is crucial to employ highly sensitive techniques to detect minimal residual disease (MRD) in preserved gonadal tissues. This study aims to identify the most effective detection method by comparing the sensitivity and specificity of reverse transcription quantitative PCR (RT-qPCR) and droplet digital PCR (ddPCR) in identifying MRD of neuroblastoma and Ewing sarcoma in ovarian and testicular tissues from patients treated for these malignancies during infancy.
CONDITIONS
Official Title
Fertility Preservation in Children With Solid Tumors: Detection of Residual Disease by a Sensitive Method
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women of any age diagnosed with a benign cyst requiring laparoscopy may be included.
- Men of any age diagnosed with non-obstructive azoospermia may be included.
- Prepubertal girls and boys diagnosed with neuroblastoma or Ewing sarcoma during infancy may be included.
- Capable of providing written informed consent to participate in the research study
- Affiliated with a social welfare service.
- For prepubertal patients, written informed consent to participate in the research study must be provided by their parents or legal guardians.
You will not qualify if you...
- None
AI-Screening
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Trial Site Locations
Total: 1 location
1
University hospital
Clermont-Ferrand, Auvergne, France, 63000
Actively Recruiting
Research Team
L
Lise Laclautre
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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