Impact of Fertility Preservation on Pregnancy and Child Health in Women with Cancer Aged 20 to 40

What this Trial Is About

Researchers are investigating whether fertility preservation affects the live birth rate and the health of mothers and their children among women diagnosed with cancer who wish to have children. The study compares cancer patients who undergo fertility preservation before receiving anti-tumor treatment to those who do not, as well as to women without cancer who conceive naturally or use assisted reproductive technology. This research is being conducted at the Clinical Center of Reproductive Medicine, First Affiliated Hospital of Nanjing Medical University, enrolling 2800 women with various malignant cancers such as breast, hematological, gynecological, nasopharyngeal, and colorectal cancers. Participants may choose to undergo fertility preservation procedures like oocyte or embryo freezing if they wish, or they may opt for observation without preservation. The study follows these groups over time to record outcomes related to cumulative live births, pregnancy complications, and the health of offspring. The observation period includes long-term monitoring to assess the effects of anti-tumor treatments on fertility and child health. Women involved in the study will be followed for up to five years, during which ovarian function, newborn malformation rates, tumor recurrence, and survival rates will be monitored. Data collection includes clinical evaluations and health assessments of both mothers and children. Statistical analysis will be conducted to compare outcomes across groups, helping to understand the impact of fertility preservation in cancer patients who desire future pregnancies.

Fertility Preservation and Pregnancy and Offspring Health Outcomes in Female Cancer